Epigenetics in health and disease. Part A / edited by Vijai Singh, Indra Mani. -- Cambridge, MA : Academic Press, 2023. – (58.178/P964/v.197)

Contents

Contributors
Preface
1. Insight into epigenetics and human diseases
    1. Introduction
    2. Epigenetic mechanisms
    3. Epigenetics and human diseases
    4. Conclusion and future perspectives
    Conflict of interest
    References
2. State-of-the-art techniques to study epigenetics
    1. Introduction
    2. Histone modification analysis
    3. DNA methylation profile analytic techniques
    4. Conclusion and future perspectives
    Conflict of interests
    References
3. Mechanisms of DNA methylation and histone modifications
    1. Introduction
    2. DNA methylation sites
    3. DNA demethylation and hydroxymethylation
    4. DNA methylation and diseases
    5. Importance of DNA methylation
    6. Modification in histone
    7. Histone modifications and diseases
    8. Conclusion
    References
 4. Epigenetics, genomics imprinting and non-coding RNAs
    1. Introduction
    2. Genomic imprinting and epigenetic alterations
    3. Immunity and epigenetic changes between generations
    4. Non-coding RNAs
    5. Conclusions and the way forward
    Competing interests
    Author contributions
    References
5. Epigenetics in cardiovascular health and disease
    1. Introduction
    2. Methodologies in the study of cardiovascular epigenetics
    3. The landscape of epigenetic research in cardiovascular disease
    4. Conclusion
    Funding
    Conflict of interests
    References
6. Histone modifications in fat metabolism and obesity
    1. Introduction
    2. Histone modifications in fat metabolism
    3. Histone modifications in obesity
    4. Conclusion and future direction
    Acknowledgment
    References
7. Role of DNA methylation in diabetes and obesity
    1. Introduction
    2. DNA methylation and diabetes
    3. DNA methylation and obesity
    4. Conclusion and future direction
    References
 8. Aging: Epigenetic modifications
    1. Introduction
    2. Key hallmarks of aging
    3. Epigenetics, aging and aging-related diseases
    4. Anti-aging strategies to improve the health span
    5. Conclusions
    Acknowledgments
    Conflict of interest
    References
 9. Epigenetics in fetal alcohol spectrum disorder
    1. Introduction
    2. DNA methylation changes in FASD
    3. Histone proteins post-translational modification (PTM) in FASD
    4. Regulation of microRNAs in FASD
    5. Conclusions
    Acknowledgment
    Conflict of interest
    References
10. Epigenetic regulation of pluripotency inducer genes NANOG and SOX2 in human prostate cancer
    1. Introduction
    2. An overview of epigenetic modifications
    3. Pluripotency factors involved in benign prostatic hyperplasia and prostate cancer
    4. Crosstalk of epigenetic machinery with signaling in prostate cancer
    5. CRISPR enables detecting reprogramming to pluripotency
    6. Conclusion
    Acknowledgments
    Funding
    References
11. Mechanistic aspects of reversible methylation modifications of arginine and lysine of nuclear histones and their roles in human colon cancer
    1. Introduction
    2. General insights into histone arginine and lysine methylation and demethylation
    3. Mechanisms of histone arginine and lysine methylation and demethylation
    4. Connecting reversible histone arginine and lysine methylations to cellular events
    5. Histone arginine and lysine methylation-based epigenetic plasticity and transcriptional regulation
    6. Interplay of arginine and lysine methylation with other histone marks at chromatin territory
    7. Impact of reversible arginine and lysine methylation of nuclear histones in colon cancer
    8. Conclusions and future prospects
    Acknowledgements
    Funding
    References
Index