Molecular, cellular, and metabolic fundamentals of human aging / Evandro Fei Fang, Linda Hildegard Bergersen, Brain C. Gilmour. -- London, UK : Elsevier Academic Press, 2023. – (59.51874/F211)

Contents

List of contributors
Foreword
Preface
 1. The hallmarks of aging: decoding aging's mystery
     1. Aging
     2. Aging research
     3. Life span and health span
     4. The hallmarks of aging
     References
SECTION I The genome
2. Epigenetic aging and its reversal
     1. Introduction to epigenetics
     2. Changes in chromatin structure during aging
     3. Changes in histones during aging
     4. Changes in histone posttranslational modifications
     5. Deoxyribonucleic acid methylation in aging
     6. Noncoding ribonucleic acids in aging
     7. Reversal of epigenetic aging
     8. Conclusions and perspectives
     References
SECTION II Metabolism, homeostasis, and communication
3. Nutrient sensing and aging
     1. AMPK signaling pathway
     2. mTOR pathway
     3. SIRT pathway
     4. IGFq pathway
     5. Calorie restriction and aging
     6, Conclusion
     References
4. Dysregulated proteostasis: mechanisms and links to aging
     1. Introduction
     2. Functional modules of the proteostasis network
     3. Proteostasis network dysregulation in aging
     4. Interplay with other aging hallmarks
     5. Targeting proteostasis for healthy aging
     6. Concluding remarks
     Acknowledgments
     References
SECTION III Autophagy and bioenergetics
5. Autophagy and bioenergetics in aging
     1. Compromised autophagy and mitophagy in aging and disease
     2. Mitochondrial dysfunction
     3. Mechanisms of mitochondrial dysfunction
     4. Dysfunctional mitochondria contribute to energy shortages and aging cells
     5. Conclusions and future perspectives
     Acknowledgments
     References
SECTION IV Senescence
6. Senescence in aging
     1. What is senescence?
     2. Current concepts of senescence in aging
     3. Factors driving and/or triggering senescence in aging
     4. Stem cell exhaustion in aging
     5. To develop senotherapies (senolytics and senomorphics) against age-related diseases and beyond
     6. Methods for analyzing and quantifying senescence in vitro and in vivo
     7. Concluding remarks
     Acknowledgments
     References
SECTION V Applications
7. Aging and the immune system
     1. Overview of immunosenescence
     2. Aging-related lymphoid organs and immunity
     3. Interplay between immunosenescence and aging process
     4. Conclusions
     References
8. Canonical and novel strategies to delay or reverse aging
     1. Approaching aging as a treatable disease
     2. Nonpharmaceutical interventions against aging
     3. Pharmaceutical treatments against aging
     4. Novel approaches to slow or reverse aging
     S. Outstanding questions and future perspectives
     Acknowledgments
     References
Index