Proteomics : a promising approach for cancer research / edited by Shafat Ali, Sabhiya Majid, Muneeb U. Rehman. -- London ; San Diego, CA : Academic Press, an imprint of Elsevier, 2023. – (64.8057/P967)

Contents

Contributors
Preface
 1. Cancer proteomics: An overview
       1. Introduction
       2, Definition and goals of proteomics
       3. Methods of protein measurement and biomarker identification
       4. Biomedical applications
       5. Mechanisms of proteomic changes in cancer
       6, Cancer biomarker applications
       7. Protocols for developing tumor biomarkers
       8. General guidelines for a good study design for biomarker discovery
       9. Applications of proteomics research in various cancers
      10. Can proteomics research findings in cancer be translated into clinically oriented research?
      11. Conclusion
      References
 2. Proteomics: A groundbreaking development in cancer biology
       1. Introduction
       2. Why proteomics?
       3, Types of proteomics
       4, Proteomics: Analytical approaches
       5. Conventional techniques
       6. Advanced techniques
       7. Gel-based approaches
       8. Quantitative techniques
       9. High-throughput techniques
      10. Proteomics: A breakthrough in cancer
      11. Oncoproteomics
      12. Proteomic variations in cancer
      13, Necessity of proteomics in cancer
      14. Heterogeneity in cancer
      15. Detecting tumor aggressiveness
      16. Personalized cancer treatment
      References
3. Proteomics: Application of next-generation proteomics in cancer research
       1. Introduction
       2. What is proteomics?
       3. Techniques in proteomics
       4. Proteomics in cancer research
       5. What is next-generation proteomics?
       6. Edman sequencing
       7. Protein microarray
       8. Functional protein microarray
       9. Analytical protein microarray
      10. Reverse-phase protein microarray
      11. Mass spectrometry-based proteomics
      12. Advancements of MS technique in cancer research
      13. Applications of MS in cancer research
    References
4. Proteomics approaches in the identification of cancer biomarkers and drug discovery
       1. Introduction
    2. Proteomics and cancer biomarkers
       3. Proteomics and drug discovery
    4. Current techniques and advancements in proteomics
    5. Challenges in proteomics
    6. Conclusion
    References
5. Proteomic profiling and its applications in cancer research
       1. Introduction
       2. Proteomic alterations in cancer
       3. Analytical approaches of proteomics
       4. Applications of proteomics in cancer
       5. Applications of cancer biomarkers
       6. Tumor aggressiveness detection
       7. Lung cancer
       8. Breast cancer
       9. Ovarian cancer
      10. Established biomarker panels: Their usefulness, challenges, and emerging potential
      11. Prostate cancer
      12. Conclusion
      References
    Further reading
6. Role of proteomics in surgical oncology
       1. Introduction
       2. Surgical oncology
       3. Proteomic techniques in surgical oncology
       4. Mass spectrometry
       5. MALDI MSI (matrix aided laser desorption ionization mass spectrometry imaging)
       6. SELDI-TOF MS
       7. Laser capture microdissection (LCM)
       8. Proteomics techniques used cancer biomarkers with special reference to surgical oncology
       9. Gastrointestinal cancer biomarker and proteomics
      10. Lung cancer biomarker and proteomics
      11. Bladder cancer and renal cancer
      12. Prostate cancer biomarker and proteomics
      13. Brain cancer and proteomics
      14. Leukemia and proteomics
      15. Conclusion
    Acknowledgment
    References
      Further reading
7. Applications of mass spectroscopy in understanding cancer proteomics
       1. Introduction
       2. Mass spectrometry-based diagnostics
       3. Mass spectroscopy imaging
       4. Protein MSI in cancer research
       5. Drug imaging in cancer research
       6. Application of MS in cancer biomarker discovery
       7. Conclusion and future perspectives
       References
  8. Proteomic approaches in the study of cancers
       1. Introduction
      2. Proteomic approaches in cancer therapy
       3. Proteomic approach in brain cancers
       4. Proteomic approach in ovarian cancers
       5. Proteomics approach in gastrointestinal cancer
       6. Proteomics approach in lung cancer
       7. Conclusion
       References
  9. Cancer proteomics: Application of case studies in diverse cancers
       1. Introduction
      2. Proteome study of gastric cancer
       3. Proteome study of esophageal cancer
       4. Proteome study of lung cancer
       5. Proteome study of genitourinary cancer
       6. Proteome study of breast cancer
       7. Proteome study of ovarian cancer
       8. Conclusion
       Acknowledgment
      References
10. The enduring interdependence of shotgun and targeted proteomics in cancer research
       1. Introduction
       2. Epidemiology of cancer
       3. Hallmarks of cancer
       4. Alterations in metabolism in cancer cells
       5. Genomic studies maybe insufficient to study cancer cell behaviors
       6. Traditional vs proteomic technologies
       7. Shotgun proteomics approach
       8. Targeted proteomics
       9. Relevance of targeted proteomics in cancer
      10. Advanced targeted methods
      11. Sample sources for biomarker research
      12. Applications of TP to major individual tumor types
      13. Concluding remarks
      References
11. Applications of proteomics in cancer diagnosis
       1. Introduction to the mechanisms of proteomic changes in cancers
       2. Proteomics techniques in cancer research: New and emerging methods, including prognostic methods
       3. Proteomics research applications in various cancers
       4. Conclusion
       Acknowledgment
       References
12. Application of plasma membrane proteomics to identify cancer biomarkers
       1. Introduction to plasma membrane and plasma membrane proteomics
       2. Plasma membrane protein alterations associated with cancers
       3. Membrane proteins as tumor targets and biomarkers
       4. Proteomics methods for study of plasma membrane proteins
       5. Role of protein markers in cancer diagnosis
       6. Membrane proteomics and biomarker discovery in various cancers
       7. Conclusion
     Acknowledgment
       References
13. Utility of proteomics and phosphoproteomics in the tailored medication of cancer
       1. Introduction
       2. Precision biomarkers based on proteomics
       3. Pathway and network analysis in proteomics
       4. Integrated data approaches
       5. Utility of proteomics and phosphoproteomics in commonly found cancers
       6. Conclusion
       References
       Further reading
14. Proteomics: A modern tool for identifying therapeutic targets in different types of carcinomas
       1. An overview of proteomics
       2. Types of proteomics
       3. Applications of proteomics
       4. Fundamental applications of proteomics
       5. Practical applications of proteomics
       6. Proteomics in cancer
       7. Analytical strategies of proteomics used in cancer research
       8. Application of proteomics in understanding cancer growth and metastasis
       9. Application of proteomics in cancer drug resistance
      10. Application of proteomics in cancer treatment using immunotherapy
      11, Proteomics in cancer biomarker identification
      12. Creation of proteomics-based cancer databases
      References
15. Cancer proteomics, current status, challenges, and future outlook
       1. Introduction
       2. Cancer proteomics
       3. Cancer growth
       4. Metastasis
       5. Drug resistance
       6. Proteomics approach in brain cancer
       7. Extracellular vesicles as brain cancer biomarkers
       8. Construction of cancer databases
       9. Recent trends in proteomics
      10. Challenges
      11. Future prospective
      References
Index