Structure and intrinsic disorder in enzymology / edited by Munishwar Nath Gupta, Vladimir N. Uversky. -- London, UK ; San Diego, CA : Academic Press, imprint of Elsevier, 2023. – (58.17435/S927s)

Contents

List of contributors
Preface
Chapter 1: Enzymology: early insights
Chapter 2: Deep mutational scanning to probe specificity determinants in proteins
Chapter 3: Protein flexibility and cryoenzymology: the trade-off between stability and catalytic rates
Chapter 4: Thermodynamic perspective of protein disorder and phase separation: model systems
Chapter 5: Structure and disorder: protein functions depend on this new binary transforming lock-and-key into structure-function continuum.
Chapter 6: Methods for measuring structural disorder in proteins
Chapter 7: Prediction of protein structure and intrinsic disorder in the era of deep learning
Chapter 8: Roles of intrinsically disordered regions in phosphoinositide 3-kinase biocatalysis
Chapter 9: The various facets of protein promiscuity: not just broad specificity of proteins
Chapter 10: Role of plasticity and disorder in protein moonlighting: blurring of lines between biocatalysts and other biologically active proteins
Chapter 11: Molten globular enzymes
Chapter 12: Intrinsic disorder and allosteric regulation
Chapter 13: Macromolecular crowding: how it affects protein structure, disorder, and catalysis
Chapter 14: Intrinsic disorder and posttranslational modification: an evolutionary perspective
Chapter 15: The roles of prion-like domains in amyloid formation, phase separation, and solubility
Chapter 16: Disordered protein networks as mechanistic drivers of membrane remodeling and endocytosis
Chapter 17: How binding to surfaces affects disorder?
Index