Droplets of life : membrane-less organelles, biomolecular condensates, and biological liquid-liquid phase separation / edited by Vladimir N. Uversky. -- London, UK : Academic Press, 2023. – (58.15/D786)

Contents

Contributor
I  Introduction to membrane-less organelles and biomolecular condensates
1. Biophysical principles of liquid-liquid phase separation
2. Major structural features of membrane-less organelles
3. Biochemical and structural biology aspects of liquid-liquid phase separation: protein side of liquid-liquid phase separation, membrane-less organelles, and biomolecular condensates
4. Biochemical and structural biology aspects of liquid-liquid phase separation: an interplay between proteins and RNA
5. Liquid-liquid phase separation and biomolecular condensates in cell quiescence
6. Multiphase complex droplets
7. Techniques for the detection and analysis of LLPS and MLOs
8. Guidelines for experimental characterization of liquid-liquid phase separation in vitro
9. Liquid-liquid phase separation at the origins of life
II  Biology of membrane-less organelle
10. Known types of membrane-less organelles and biomolecular condensates
11. Active regulation mechanisms of LLPS and MLOs biogenesis
12. Interactions and interplay of MLOs with classical membrane-bound organelles
13. Intrinsically disordered regions: a platform for regulated assembly of biomolecular condensates
14. MLOs and control of metabolic pathways
15. LLPS and regulation of Transmembrane signaling
16. Phase separation in chromatin-based intranuclear processes
17. MLOstasis: liquid-liquid phase separation and biomolecular condensates in cell competition, fitness, and aging
18. Stress, membraneless organelles, and liquid-liquid phase separation
19. Roles of phase separation and condensates in autophagy
20. Liquid-liquid phase in anhydrobiosis
21. Plant biomolecular condensates
22. Droplets of life: role of phase separation in virus replication and compartmentalization
III  Pathological roles of LLPS
23. Liquid-liquid phase separation in neurodegenerative diseases
24. Emerging roles of liquid-liquid phase separation and membraneless organelles in cancer progression
25. Liquid-liquid phase separation, membrane-less organelles, and biomolecular condensates in cardiovascular disease
26. Phase separation and infectious diseases
Index