International review of cell and molecular biology. Volume 349, Immunobiology of dendritic cells. Part B / edited by Claire Lhuillier, Lorenzo Galluzzi. -- Cambridge, MA : Academic Press, 2019. – (58.15 /I61 /v.349)

Contents

Contributors

Preface: Dendritic cells: Master regulators of innate and adaptive immunity

1.  Origin and development of classical dendritic cells

     1. Introduction

     2. Classical dendritic cell subsets

     3. Growth factors dependence of classical dendritic cell subsets

     4. Bone marrow progenitors for classical dendritic cells

     5. Circulating precursors for classical dendritic cells

     6. Peripheral niches

     7. Transcriptional regulation of classical dendritic cell development

     8. Conclusion and open questions

     Acknowledgment

     References

     Further reading

2.  Transcriptional control of dendritic cell development and functions

     1. Introduction

     2. The unique functions of DCs

     3. Overview about antigen uptake, processing and presentation by DCs

     4. Phenotypical characterization of cDCs and pDCs

     5. Identification and functional specialization of the cDC1 subset

     6. Identification and functional specialization of the cDC2 subset

     7. cDC1 and cDC2 and the induction and maintenance of tolerance

     8. Identification and functional specialization of pDCs

     9. Origin, identification and functional specialization of Langerhans cells

     10. Identification and functional specialization of MoDCs

     11. Phenotypical characterization, functional specialization, and presence of DC subsets in human tissues

     12. The development of early DC progenitors within the bone marrow

     13. Crucial factors for DE development: Flt3 and Flt3L, GM-CSF and GM-CSFR

     14. Transcriptional regulation of DC differentiation and function

     15. Impact of post-transcriptional regulation by microRNAs

     16. Epigenetic regulation of DCs

     17. Conclusions

     Acknowledgments

     Statement

     References

3.  The impact of endoplasmic reticulum stress responses in dendritic cell immunobiology

     1. A brief introduction to dendritic cell biology

     2. ER stress responses in DCs

     3. Concluding remarks

     Acknowledgments

     Competing interest

     References

4.  The versatile plasmacytoid dendritic cell: Function, heterogeneity, and plasticity

     1. Introduction

     2. Functional diversity of plasmacytoid dendritic cells

     3. Sources of pDC functional diversity: Developmentally encoded subsets versus environmentally mediated plasticity

     4. Concluding remarks

     Acknowledgments

     References

5.  Dendritic cell extracellular vesicles

     1. Introduction

     2. Molecular identity of dendritic cell-derived extracellular vesicles

     3. Diversity of extracellular vesicles from dendritic cells

     4. The journey of an extracellular vesicle: From its biogenesis to its final destination in the target cell

     5. Role of dendritic cell-derived extracellular vesicles as modulators of immune responses

     6. Clinical application of dendritic cell-derived extracellular vesicles

     7. Concluding remarks and perspectives

     Acknowledgments

     References

6.  Ex vivo dendritic cell generation--A critical comparison of current approaches

     1. Cytokine signals

     2. Physiological signals for DC differentiation

     3. Gene engineering tools

     4. Clinical trials of DC-based vaccines

     5. Concluding remarks

     Conflict of interest

     References