Molecular biology of neurodegenerative diseases : visions for the future. Part A / edited by David B. Teplow. -- Cambridge, MA : Academic Press, 2019. – (58.178 /P964 /v.168)

Contents

Contributors

Preface

Section I

Targetting AD

1. Fluid biomarker-based molecular phenotyping of Alzheimer's disease patients in research and clinical settings

2. Tracking down a missing trigger for Alzheimer's disease by mass spectrometric imaging based on brain network analysis

3. Using mirror-image peptides to enhance robustness and reproducibility in studying the amyloid ~-protein

Section II Etiology of AD

4. In search of pathogenic amyloid I~-peptide in familial Alzheimer's disease

5. Biology of splicing in Alzheimer's disease research

6. Acquired cerebral amyloid angiopathy: An emerging concept

Section III Neuroimmunology of AD

7. Blood-brain barrier and innate immunity in the pathogenesis of Alzheimer's disease

8. Gut microbiota mediated allostasis prevents stress-induced neuroinflammatory risk factors of Alzheimer's disease

9. Neuroimmune interactions in Alzheimer's disease--New frontier with old challenges?

Section IV AD therapy

10. Alzheimer's therapy development: A few points to consider

11. The next steps in curing Alzheimer's disease

12. Future horizons in Alzheimer's disease research

13. Why delay in effective treatment for Alzheimer's disease and related conditions

14. Restoring synoptic function through multimodal therapeutics

15. Disease-modifying therapy for proteinopathies: Can the exception become the rule?

16. Combination therapy for Alzheimer's disease and related dementias

Section V Alpha-synucleinopathies

17. Can infections trigger alpha-synucleinopathies?

18. Prion-like propagation of α-synuclein in neurodegenerative diseases

Section VI Model systems

19. Yeast models of neurodegenerative diseases

Index