International review of cell and molecular biology. Volume 350, Biology of the endoplasmic reticulum / edited by Oliver Kepp, Lorenzo Galluzzi. -- Cambridge, MA : Academic Press, 2020. – (58.15 /I61 /v.350)

Contents

Contributors

Preface: Endoplasmic reticulum in health and disease

1. Endoplasmic reticulum stress in the cellular release of damage-associated molecular patterns

    1. ER stress

    2. Danger signaling

    3. Emission of immunostimulatory DAMPs during ICD

    4. ROS production, ER stress and ICD in anticancer therapy

    5. ER stress and DAMP emission in infection and inflammatory diseases

    6. Concluding remarks

    Acknowledgments

    References

2. Emerging roles of the unfolded protein response (UPR) in the nervous system: A link with adaptive behavior to environmental stress?

    1. Introduction

    2. Proteostasis and the unfolded protein response

    3. Linking the UPR to behavior from an evolutionary perspective

    4. Interplay between circadian clock and UPR

    5. Cellular stress responses in behavioral stress

    6. Immune responses under environmental stress. Role of UPR and therapeutics implications

    7. Concluding remarks

    Acknowledgments

    Author contributions

    References

3. Type I interferons and endoplasmic reticulum stress in health and disease

    1. Introduction

    2. Type I interferons: An introduction

   3. ER stress and inflammation: An introduction

    4. ER stress and type I IFNs: There and back again

    5. Conclusion

    Acknowledgments

    References

4. The role of mitochondria-associated membranes in cellular homeostasis and diseases

    1. Introduction

    2. MAMs structure and composition

    3. Function and signaling role of MAMs in cellular pathways

    4. MAMs in diseases

    5. Conclusions

    Acknowledgments

    References

5. Sarcoplasmic reticulum and calcium signaling in muscle cells: Homeostasis and disease

    1. Introduction

    2. SR/ER structure

    3. Ca2+ cell physiology in striated muscle cell

   4. Ca2~ cell physiology in smooth muscle

    5. SR/ER dysfunction and diseases

    6. Concluding remarks

    Acknowledgments

    References

6. Endoplasmic reticulum in viral infection

   1. Introduction

    2. The endoplasmic reticulum or ER

   3. Exploitation of ER functions by viruses

    4. Conclusions and future perspectives

    References

7. Targeting endoplasmic reticulum stress and autophagy as therapeutic approaches for neurological diseases

   1. Introduction

    2. The interplay of ER stress and autophagy

    3. Involvement of CNS cells

    4. Brain infections

    5. CNS injury

   6. Neurodegenerative disorders

    7. Conclusions and future perspectives

    References