Mesenchymal stem cells in human health and diseases / edited by Ahmed H. K. El-Hashash. -- London : Academic Press, 2020. – (58.15 /M578)

Contents

Contributors

About the editor

Foreword

Foreword

Preface

Acknowledgments

 1.  Mesenchymal stem cells in regenerative medicine and diseases: hope for better human health

       References

       Further reading

 2.  Application of mesenchymal stem cells in human diseases

       Introduction: background and driving forces

       History of mesenchymal stem cells

       Function of mesenchymal stem cells

       Controversy over and expectations for mesenchymal stem cells

       Conclusion

       References

 3.  Immunoregulatory properties of mesenchymal stem cells and their application in immunotherapy

       Immunomodulatory effects of mesenchymal stem cells

       Mechanisms of antiinflammatory effects of mesenchymal stem cells

       Prospective and concluding remarks

       References

4.  Stem cell therapies in ocular repair, regeneration, and diseases

      Introduction

      Stem cell therapy for retinal diseases

      Stem cell therapy for corneal diseases

      Corneal stem cell types

      Corneal and limbal stem cell markers

      Stem cell therapeutic approaches for corneal diseases

      Limbal stem cell deficiency

      Ex vivo expansion limbal stem cell transplantation

      Conclusions, challenges and future directions

      References

      Further reading

5.  Applications of the stem cell secretome in regenerative medicine

      Introduction

      Modulation of the stem cell secretome profile

      Application of the stern cell secretome in CNS disorders

      Concluding remarks

      References

6.  Innovation in induced mesenchymal stem cell uses in therapy

      Introduction

      Major sources of induced mesenchymal stromal/stem cells

      Induced mesenchymal stromal/stem cell applications in cell therapy

      Conclusion

      References

7.  Role of mesenchymal stem cells in bone fracture repair and regeneration

      Introduction

      Sources of mesenchymal stem cells for bone regeneration

     Mesenchymal stem cell homing in bone regeneration

      Molecular mechanisms affecting mesenchymal stem cell homing

      External factors affecting mesenchymal stem cell homing

      The application of mesenchymal stem cells in bone tissue regeneration

      Clinical consequences

      Conclusion

      References

8.  Tendon stem cells and their interaction with microenvironments

      Introduction

      Isolation and culture of tendon stem/progenitor cells

      Characterization of tendon stem/progenitor cells

      Culture conditions

      Cell passage and senescence

      Growth factors

     Mechanical stimulation

      Extracellular matrix and scaffold

      Clinical relevance: the role of tendon stem/progenitor cells in tendon disease

      Conclusion and forecast

      Acknowledgments

      References

9.  Mesenchymal stem cell roles in osteoarthritis (joint) disease

      Conclusion

      References

      Further reading

10.  Mesenchymal stem cells and cancer therapy

      Introduction

      The application of mesenchymal stem cells in cancer treatments

      Limiting factors of the mesenchymal stem cell-mediated cancer therapies

      Conclusions and future directions

      References

11.  Mesenchymal stem cells in human health and diseases: general discussion, remarks, and future directions

      References

Index