International review of cell and molecular biology. Volume 354 / edited by Lorenzo Galluzzi. -- Cambridge : Academic Press, 2020. – (58.15 /I61 /v.354)

Contents

1. The biology of Lonp1: More than a mitochondrial protease

    1. Introduction

    2. Structure and functions of human LONP1

    3. The evolutionary ancestry of LONP1 in the tree of life

    4. Cellular localization of LONP1

    5. The role of LONP1 in regulating metabolism

    6. Genetics of Lonp1

    7. LONP1 and human diseases

    8. LONP1 and cancer

    9. Hints from animal models

    10. Conclusions

    Acknowledgments

    References

2. Molecular mechanisms of selective autophagy in Drosophila

    1. Introduction

    2. Developmental regulation via autophagy

    3. Selective macroautophagy in Drosophila

    4. Selective autophagy receptors and adaptors in Drosophila

    5. Concluding remarks

    Acknowledgments

    References

3. Links between cancer metabolism and cisplatin resistance

    1. Introduction

    2. Past, present and future of platinum drugs

    3. Cisplatin mechanism of action

    4. Molecular mechanisms of cisplatin resistance

    5. Metabolic rewiring as chemoresistance mechanism

    6. Concluding remarks

    References

4. New emerging roles of Polycystin-2 in the regulation of autophagy

    1. Introduction

    2. The protein structure of PC2

    3. PC2 as a calcium channel: Regulation and partners

    4. Post-translational modifications of PC2 regulate its activity and subcellular location

    5. Diseases associated with PC2 alterations

    6. Autophagy: An overview

    7. Mechanisms of autophagy

    8. Polycystin-2: A novel autophagy regulator?

    9. Concluding remarks

    Acknowledgments

    References

5. Pharmacological methods to transcriptionally modulate double-strand break DNA repair

     1. Introduction

     2. Mechanisms of DSB repair

     3. Transcriptional regulation of DSB repair factors

     4. Histone deacetylase (HDAC) inhibitors

     5. Bromodomain (BRD) and extra-terminal domain (BET) inhibitors

     6. Androgen signaling pathway inhibitors

     7. PI3K inhibitors

     8. Anti-angiogenic therapy

     9. Conclusions and future directions

     10. Methods

     Acknowledgments

     References

6. Evolutionary insights into the aphid genome: Aphid genomics between quality problems and intriguing perspectives

    1. Introduction

    2. Looking for improved genome quality

    3. Holocentric chromosomes, gene mapping and synteny

    4. Less sex, more gene duplications

    5. A genome-scale view of aphid-plant associations and their role in aphid diversification

    6. Future perspectives

    References

7. Stratifying nutritional restriction in cancer therapy: Next stop, personalized medicine

    1. The rationale behind nutritional interventions in cancer therapy

    2. Preclinical research of nutrient restriction as adjuvant to cancer therapy

    3. Clinical studies investigating nutrient restriction as adjuvant to cancer therapy

    4. Conclusion

    References

8. The biology of vascular calcification

    1. The cellular compartment

    2. The extracellular compartment

    3. Pro-osteogenic and anti-calcifying factors

    4. Vascular calcification in diseases

    5. Treatments targeting the calcification process

    6. Conclusive remarks

    Acknowledgments

    References