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Principles of nutrigenetics and nutrigenomics : fundamentals of individualized nutrition / edited by Raffaele de Caterina, J. Alfredo Martinez, Martin Kohlmeier. -- London : Academic Press, an imprint of Elsevier, c2020. – (61.115/P957)

Contents

Contributors

Editor Biographies

Preface

Introduction

I  The Biological Basis of Heritability and Diversity

1. The Nature of Traits, Genes and Variation

2. Molecular Biology of Genetic Variants

3. Regulation of Gene Expression

4. The Role of Nutrition in DNA Replication, DNA Damage Prevention and DNA Repair

5. Genotyping and Sequencing

6. RNA Analyses

7. Methods for Global Nutrigenomics and Precision Nutrition

8. Epigenetic Analyses Tools for Nutrition Research

9. Proteomic Analyses

10. Metabolomics for Biomarker Discovery and to Derive Genetic Links to Disease

11. Metagenomics

12. A Broader View on Omics and Systems Biology

13. Study Designs in Genomic Epidemiology

14. Epistemology of Nutrigenetic Knowledge

II  Nutrigenetics

15. Nutrigenetics and the Early Life Origins of Health and Disease: Effects of Protein Restriction

16. Maternal Perinatal Nutrition and Offspring Programming

17. Introduction to Epigenetics

18. Genetics of Chrononutrition

19. Screening for Inborn Errors of Metabolism

20. Genomics of Eating Behavior and Appetite Regulation

21. Genetics of Body Composition: From Severe Obesity to Extreme Leanness

22. Genetic Regulation of Energy Homeostasis: Obesity Implications

23. Genetic Variations With Influence on the Individualized Response to Weight Loss Diets: FTO as Evidence

24. Genetic Variation in the Response to Exercise Training: Impact on Physical Fitness and Performance

25. Genetic Variations Impacting the Response to Defined Diets

26. Carbohydrates and Nutrigenetics

27. Gene-Diet Interactions and Cardiovascular Diseases: Saturated and Monounsaturated Fat

28. Nutrigenetics: Omega-3 and Omega-6 Fatty Acids

29. Nutrigenetics and Blood Cholesterol Levels in Response to Plant Sterols

30. Genetic Individuality and Alcohol Consumption

31. Vitamin A and Other Carotenoids

32. Vitamin D

33. Genetic Determinants of Vitamin E Status

34. Vitamin K

35. Vitamins as Cofactors for Energy Homeostasis .and Their Genomic Control, With Special Reference to Biotin, Thiamine, and Pantothenic Acid

36. Impact of Genetic Variation on Vitamin C Status

37. Riboflavin

38. Niacin

39. Folate and Vitamins B6 and B12

40. The Nutrigenetics of Choline

41. Electrolytes

42. Iron

43. Trace Elements

44. Polyphenols and Nutrigenetic/Nutrigenomic Associations With Obesity-Related Metabolic Diseases

45. Caffeine

46. Phytanic Acid Metabolism in Health and Disease

47. Nutrigenetics, Fatty Acids, and Cognition

48. The Nutrigenetics of Cardiovascular Disease

49. Hemostasis and Thrombosis

50. Diet-Gene Interactions: Perspectives in Insulin Resistance and Type 2 Diabetes

51. Nutrigenetics of Bone Health

52. Nutrients and Genes in the Liver: The Central Role of Liver X Receptor in Lipogenesis

53. Hyperuricemia and Gout

54. Aging: Mechanisms, Signaling and Dietary Intervention

55. Epigenetics in Food Allergies: The Missing Piece of the Puzzle

56. Gut Microbiota and Their Influence on Response to Food

III  Nutrigenomics

57. Nutrients and Gene Expression in Development

58. Nutrients, Obesity and Gene Expression

59. Nutrients and Gene Expression in Type 2 Diabetes

60. Gene Expression in Dyslipidemias

61. Nutrients and Gene Expression in Inflammation

62. Nutrients and Gene Expression in Cardiovascular Disease

63. Nutrients and Gene Expression in Cancer

64. Nutrients and Gene Expression Affecting Bone Metabolism

IV  Translational Nutrigenetics and Nutrigenomics

65. Precision Nutrition Interventions Based on Personalized Genetic Advice

66. Genetically Informed Nutrition Guidance

67. Nutrigenomics of Food Pesticides

68. Pharmaconutrigenetics: The Impact of Genetics on Nutrient-Drug Interactions

69. Setting Genome-Directed Guidelines and Algorithms

70. Direct-to-Consumer Testing

71. Privacy Risks and Protective Measures

72. Ethical Considerations in Nutrigenetics and Nutrigenomics

73. Impact of Nutrigenetics and Nutrigenomics on Society

Index