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Advances in immunology. Volume 141 / edited by Frederick W. Alt. -- Amsterdam : Elsevier, c2019. – (58.691/A244/v.141) |
Contents
Contributors
1. Multilayer regulation of CD4 T cell
subset differentiation in the era of single cell genomics
1.
CD4 T cell subsets: Traditional lineage paradigm
2.
CD4 T cell plasticity versus functional heterogeneity
3.
Regulatory networks of CD4 T cell differentiation and functions
4.
Lineage and functional modularity in follicular helper T cells and follicular
regulator/T cells
5.
Concluding remarks
Acknowledgments
References
2. Transcription factories in Igκ allelic
choice and diversity
1.
Igκ structure
2.
Generation of Vκ-Jκ repertoires and unanswered questions
3.
Recruitment of Vκ gene containing TADs to transcription factories
4.
Regulation of Vκ transcription by cyclin D3
5.
Chromatin loop structure is constrained in nuclear niches
6.
Summary
References
3. Cis- and trans-factors affecting AID
targeting and mutagenic outcomes in antibody diversification
1.
AID-initiated antibody diversification processes
2.
Specific targeting of AID mutagenic activity
3.
Mutagenic outcome of somatic hypermutation
4.
Deletional outcome of class switch recombination (CSR)
5.
Unleash the mutagenic power of AID in diversifying base editors (DBEs)
6.
Perspective
Acknowledgments
References
Further reading
4. Signaling control of antibody isotype
switching
1.
Overview of antibody-mediated humoral immunity and class switch recombination
2.
Different receptors that signal to regulate CSR
3.
AID and its regulation
4.
Signaling balance for CSR
Acknowledgments
Compliance with ethics guidelines
References
