Basic immunology : functions and disorders of the immune system / Abul K. Abbas, MBBS, Andrew H. Lichtman, MD, PhD, Shiv Pillai, MBBS, PhD ; illustrations by David L. Baker. -- 6th edition -- Philadelphia, PA : Elsevier, 2020. – (63.17/A122/6th ed.)

Contents

1 Introduction to the Immune System, 1

   Nomenclature, General Properties, and Components

2 Innate Immunity, 23

   The Early Defense Against Infections

3 Antigen Capture and Presentation to Lymphocytes, 51

   What Lymphocytes See

4 Antigen Recognition in the Adaptive Immune System, 73

   Structure of Lymphocyte Antigen Receptors and Development of Immune Repertoires

5 T Cell-Mediated Immunity, 96

   Activation of T L Lymphocytes

6 Effector Mechanisms of T Cell-Mediated Immunity, 119

   Functions of T Cells in Host Defense

7 Humoral Immune Responses, 137

   Activation of B Lymphocytes and Production of Antibodies

8 Effector Mechanisms of Humeral Immunity, 158

   Elimination of Extracellular Microbes and Toxins

9 Immunologic Tolerance and Autoimmunity, 177

   Se/f-Nonself Discrimination in the Immune System and Its Failure

10 Immunology of Tumors and Transplantation, 196

   Immune Responses to Cancer Cells and Normal Foreign Cells

11 Hypersensitivity, 218

   Disorders Caused by immune Responses

12 Congenital and Acquired Immunodeficiencies, 235

   Diseases Caused by Defective Immunity

Selected Readings, 252

Glossary, 260

Appendix I: Principal Features of Selected CD Molecules, 288

Appendix II: Cytokines, 296

Appendix III: Clinical Cases, 300

Index, 313