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Computational immunology. Shyamasree Ghosh Basics / -- Boca Raton : CRC Press, c2020. – (58.6911 /C738b) |
Contents
Preface
Acknowledgments
Author
About the Book
List of Abbreviations
Chapter 1
Overview of Immunology and Computational Immunology
1.1
Introduction
1.2
History of the Science of Immunology
1.3
Innate Immune System
1.4
Adaptive Immune System
1.5
Clonal Selection
1.6
Antigen
1.7
Immune Cells and Organs
1.8
Antigen Processing and Presentation
1.9
Antibody-Dependent Cellular Cytotoxicity
1.10
Immunodeficiencies
1.11
Immune Tolerance and Autoimmunity
1.12
Hypersensitivity/Allergy
1.13
Infection
1.14
Vaccination
1.15
Tracing the Origin of the Applications of the Science of Computation in
Science, Biology, and Immunology
1.16
History of Computational Immunology
1.17
The Current Developments of Computational Immunology
1.18
Different Immunological Databases
1.19
Computational Immunology and the Biology of Disease
1.20
Discussions
References
Chapter 2
Immune Organs and Cells, Antigen, and Antibody, B-Cell, and T-Cell
Development
2.1
Introduction
2.2
Immune Cells and Organs
2.3 Antigen
2.4
Immunoglobulin
2.5
B-Cell Development
2.6
Activation of B Cells
2.7
Antibody Diversity
2.8
Immunoglobulin Superfamily Members
2.9
T-Cell Maturation
2.10
The Structure of the T-Cell Receptor Complex
2.11
Function of TCR
2.12 TCR Genes and Its Organisation
2.13
Computational Immunology and Study of Immune Cells
2.14
Discussion
References
Chapter 3
Antigen Processing and Presentation
3.1
Introduction
3.2
Major Histocompatibility Complex
3.3
Classes of MHC Molecules
3.4
Associated Molecules Involved in Antigen Processing and Presentation
Pathway
3.5
Functions of MHC
3.6
MHC and Disorders
3.7
Antigen Presentation and Processing
3.8
Endocytic Pathway or Exogenous Antigens
3.9
Processing of Endogenous Antigens or the Cytosolic Pathway
3.10
Cross Presentation of Exogenous Antigens
3.11
Presentation of Non-peptide Antigens
3.12
Computational Immunology and Antigen Processing and Presentation
3.13
Discussion
References
Chapter 4
Innate Immunity
4.1
Introduction
4.2
Barriers to Infection
4.3
Discussion
References
Chapter 5
Inflammation
5.1
Introduction
5.2
Mechanism
5.3
PAMPs and DAMPs
5.4
TLRs
5.5
RIG-I-Like Receptors
5.6
NOD-Like Receptors
5.7
Tumour Necrosis Factor
5.8
Selectins and Integrins
5.9 G
Protein-Coupled Receptors
5.10
C5a Receptor and Formyl Peptide Receptors
5.11
Fc Receptors
5.12 Acute Phase Proteins (APPs)
5.13
Acute Phase Response
5.14
C-Reactive Protein
5.15
Acute Inflammation
5.16
Chronic Inflammation
5.17
Inflammation and Disease
5.18
Computational Immunology and Inflammation Biology
5.19
Discussion
References
Chapter 6
Infection and Immunity
6.1 Introduction
6.2
Infectious Diseases: A Historical Perspective
6.3
Viruses
6.4
Bacteria
6.5
Fungi
6.6
Helminths
6.7
Protozoa
6.8
Arthropod-Borne Diseases
6.9
Prions and Diseases
6.10
Understanding Host-Parasite Interaction
6.11
Molecular Mimicry
6.12
The HIV Virus
6.13
Computational Immunology and the Biology of Infection
6.14
Discussion
References
Chapter 7
Transplantation Immunology
7.1
Introduction
7.2
Organ Transplantation: A Historical Perspective
7.3
Histocompatibility and Transplantation Biology from a Historical
Perspective
7.4
The Immunology of Transplantation
7.5
Transplantation Antigens
7.6
Types of Organ/Tissue Graft
7.7
Graft Rejection
7.8
Coping with Graft Rejection
7.9
Immunologically Privileged Sites
7.10 Immunosuppression
7.11
Allografts and Immune Tolerance
7.12
Privileged Sites: The Eye
7.13
Organs and Transplantation
7.14
Bottlenecks in Transplantation Research
7.15
Computational Immunology in Transplantation Biology
7.16
Discussion
References
Chapter 8
Vaccines
8.1
Introduction
8.2
Vaccination: A Brief Journey through History
8.3
Types of Immunisation
8.4
Immunisation
8.5
Vaccines Stimulating Immunity
8.6
Different Vaccines
8.7
Vaccines Approved by the U.S. Food and Drug Administration ...
8.8
Vaccines under Development
8.9
World Health Organisation and Immunisation
8.10
Cancer and Vaccination
8.11
Edible Vaccines
8.12
Reverse Vaccinology
8.13
Computational Immunology and Vaccination: An Overview
8.14
Discussion
References
Chapter 9 Diseases due to Abnormalities of the Immune
System
9.1
Introduction
9.2
Hypersensitive Reactions
9.3
Autoimmunity
9.4
Primary Immunodeficiency
9.5
Secondary Immunodeficiency
9.6
Combined Immunodeficiencies (CIDs)
9.7
Computational Immunology and Immune Disorders
9.8
Discussion
References
Chapter 10 Cancer Biology
10.1
Introduction
10.2
Cancer: A Global Perspective
10.3
Epidemiology of Cancer
10.4
Types of Cancer
10.5
Biology of Cancer
10.6
Immune Responses against Tumour and Immune Surveillance
10.7
Evasion of the Immune System in Cancer
10.8
Cancer Therapy
10.9
Computational Immunology and Cancer
10.10
Discussion
References
Glossary
Index
