Progress in molecular biology and translational science. Volume 159 / edited by David B. Teplow. -- Cambridge, MA : Academic Press, an imprint of Elsevier, 2018. – (58.178/P964/v.159)

Contents

Contributors

Preface

1.  Targeting the Recently Deorphanized Receptor GPR83 for the Treatment of Immunological, Neuroendocrine and Neuropsychiatric Disorders

     1. Introduction

     2. Expression and Significance of GPR83 in the Brain

     3. Role of GPR83 in Immune Function

     4. Current Understanding of GPR83 and PEN

     5. Conclusions

     Acknowledgment

     References

2.  Arrestins in the Cardiovascular System: An Update

     1. Introduction

     2. Cardiovascular Adrenergic Receptors and βarrestins

     3. Cardiovascular Angiotensin II Receptors and βarrestins

     4. Other Cardiovascular GPCRs and βarrestins

     5. Therapeutic Implications of the Functional Divergence of Cardiovascular βarrestins

     6. Conclusions and Future Perspectives

     References

3.  Global Aquatic Hazard Assessment of Ciprofloxacin: Exceedances of Antibiotic Resistance Development and Ecotoxicological Thresholds

     1. Background

     2. Materials and Methods

     3. Results and Discussion

     4. Conclusions

     References

4.  Group I Intron-Based Therapeutics Through Trans-Splicing Reaction

     1. Introduction

     2. Group I Intron

     3. Group I Intron as Therapeutics

     4. Concluding Remarks

     Acknowledgments

     References

5.  Major 3'-5’ Exoribonucleases in the Metabolism of Coding and Non-coding RNA

     1. Introduction

     2. Polynucleotide Phosphorylase

     3. RNase II

     4. RNase R

     5. Concluding Remarks

     Acknowledgments

     References

6.  Different Methods of Delivering CRISPR/Cas9 Into Cells

     1. Introduction

     2. Delivery Methods of CRISPR/Cas9 for Genome Editing

     3. Opportunities and Challenges in CRISPR/Cas9 Delivery

          to Stem Cells

     4. Conclusions and Future Perspectives

     Acknowledgments

     References

7.  Structural Simplicity and Mechanistic Complexity in the Hammerhead Ribozyme

     1. Background and Structural Overview

     2. Fast Minimal Hammerhead Ribozymes

     3. Acid-Base Catalysis and the Hammerhead Ribozyme

     4. Is the Hammerhead Ligation Reaction the Reverse of the Cleavage Reaction?

     5. Do Cooperative Interactions in the Hammerhead Ribozyme Facilitate General Base Catalysis in the Cleavage Reaction?

     6. Summary and Concluding Remarks

     References

Index