Progress in molecular biology and translational science. Volume 160 / edited by David B. Teplow. -- Cambridge, MA : Academic Press, an imprint of Elsevier, 2018. – (58.178/P964/v.160)

Contents

Contributors

Preface

1. Adult Stem Cells for Regenerative Therapy

     1. Introduction

     2. Adult Stem Cells Therapy for the Heart

     3. Adult Stem Cell Therapy for Neurogenesis

     4. Adult Stem Cell Therapy for Diabetes Mellitus

     5. Stem Cell Therapy for the Ophthalmic Disorders

     6. Challenges and Future Direction

     7. Concluding Remarks

     Acknowledgments

     References

2.  Hair Follicle-Associated Pluripotent(HAP) Stem Cells

     1. Introduction

     2. HAP Stem Cells

     3. Growth of Nerves in Histoculture From HAP Stem Cells

     References

     Further Reading

3.  Fluorescent Proteins as Sensors for Cellular Behavior in Mice

     1. Properties of GFP and Other Fluorescent Proteins as Imaging Agents

     2. Intravital Imaging Using Fluorescent Proteins

     3. Cancer Cell Trafficking in Blood Vessels

     4. Cancer Cell Trafficking in Lymphatic Channels Imaged With RFP and RFP

     5. Cancer Neurogenesis

     6. Metastatic Route Mapping at the Single-Cell Level in Real Time

     7. Comparison of Orthotopically-and Subcutaneously-Transplanted Tumors at the Cellular Level

     8. Other Metastatic Models imaged With GFP

     9. Brain Metastasis

     10. Role of Stroma and Other Host Cells in Metastasis

     11. Imageable Color-Coded Tumor-Host Models

     12. Imaging Quiescent or Dormant Cancer Cells

     13. New In Vivo GFP Imaging Technology

     14. Conclusions

     References

4. Arrestins: Introducing Signaling Bias Into Multifunctional Proteins

     1. Wild-Type Arrestins: Too Many Functions

     2. Receptor Specificity: Selective Targeting of Certain GPCRs?

     3. Making Arrestins Phosphorylation Independent

     4. Channeling the Signaling Toward or Away From Selected Pathways

     5. "Designer Arrestins": A Roadmap or a Dream?

     Acknowledgments

     References

5.  Analysis of Biased Agonism

     1. Introduction

     2. A single-Receptor View of Drug Action

     3. Relationship Between the Simple Receptor-State Model and Agonist-Receptor-G Protein Interactions

     4. Relationship Between the Receptor-State Parameters and the More Conventional Parameters of the Receptor Population, Affinity, and Efficacy

     5. General Strategy for Estimating Receptor-State Parameters From Functional Data

     6. Examples of Experimental Paradigms and Methods of Analysis

     7. Interpretation of Receptor-State and Population Analysis Within the Context of Agonist Bias

     8. Establishment and Standardization of Quantitative In Vitro and In Vivo Assays for Drug Screening

      References

6.  Effects of Estrogens on Central Nervous System Neurotransmission: Implications for Sex Differences in Mental Disorders

     1. Introduction

     2. CNS Neurotransmission Involved in Reward Circuitry

     3. Effects of Estrogens on CNS Neurotransmission

     4. Conclusions

     Acknowledgments

     References

Index