International review of cell and molecular biology. volume 343 / edited by Lorenzo Galluzzi. -- Amsterdam : Academic Press, c2019. – (58.15/I61/v.343)

Contents

Contributors

1. The Molecular and Cellular Regulation of Brassicaceae Self-Incompatibility and Self-Pollen Rejection

    1. Introduction

    2. Role of Small RNAs in Dominant-Recessive Interactions Between 5-Haplotypes

    3. Use of the Transgenic Arabidopsis thaliana Model System to Further Explore SRK Function, Localization, and Modification

    4. Investigating the Self-Incompatibility Signaling Pathway: MLPK and ARC1

    5. Cellular Responses Triggered by ARC1

    6. Calcium Fluxes and Autophagy in Self-Incompatibility Signaling

    7. Diversity in Brassicaceae Self-Incompatibility and Unilateral incompatibility

    8. Conclusions and Future Directions

    Acknowledgments

   References

2. Regulation of Plant Immunity by the Proteasome

    1. Introduction

    2. E3 Ligases With Immune-Related Functions

    3. The Role of General Proteasome Components in Plant Immunity

    4. Conclusions and Perspectives

    References

3. Role of the Ubiquitin Proteasome System in Plant Response to Abiotic Stress

    1. Introduction

    2. The Ubiquitin Proteasome System

    3. UPS-Dependent Regulation of Abiotic Stress Response

    4. Modes of E3 Regulation of Abiotic Stress Signaling

    5. Complexity of Ubiuitin-Dependent Regulation of Stress Signaling

    References

4. Glycosylation and Antitumor Immunity

    1. Introduction

    2. Glycosylation and Protein Modification: An Overview

    3. Glycosylation's Role in Cancer

    4. Glycosylation and Tumor Immune Evasion

    5. Endogenous Lectins and Adaptive Immunity

    6. The Immunosuppressive Nature of Glycosphingolipids

    7. Sialic Acid Domains and Antitumor Immunity

    8. Glycan-Based Cancer Therapies

    9. Conclusion

    Conflicts of Interest

    References

5. Emerging Themes in PDZ Domain Signaling: Structure, Function, and Inhibition

    1. Introduction

    2. Cellular Function of PDZ Domain-Containing Proteins and Their Link to Disease

    3. Canonical PDZ Domain-Binding Motifs and Novel Ligands

    4. Inhibition of PDZ Domain/Ligand Interactions

    5. Regulation of PDZ Domain/Ligand Interactions

    6. Conclusions

    Acknowledgments

    References

6. Cross Talk Networks of Mammalian Target of Rapamycin Signaling With the Ubiquitin Proteasome System and Their Clinical Implications in Multiple Myeloma

    1. Introduction

    2. Mammalian Target of Rapamycin Signaling Pathways

    3. Interplay Between Mammalian Target of Rapamycin Pathway and the Ubiquitin Proteasome System

    4. Targeting the mTOR Pathway in MM

    5. Conclusion

    Acknowledgments

    References