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International review of cell and molecular biology. Volume 344, Nucleic acid sensing and immunity. Part A / edited by Claire Vanpouille-box, Lorenzo Galluzzi. -- Amsterdam : Academic Press, c2019. – (58.15/I61/v.344) |
Contents
Contributors
Nucleic Acid Sensing at the Interface
Between Innate and Adaptive Immunity
1.
Discrimination Between Self and Non-Self-Nucleic Acids by the Innate
Immune System
1. Introduction
2. Intracellular Nucleic Acid Sensors
3. Extracellular Nucleic Acid Recognition
4. Modifications Enabling DNA Discrimination
5. Modifications Allowing RNA Discrimination
6. Endogenous Nucleic Acids as DAMPs
7. Endogenous Nucleotides Facilitate Inflammation
8. Conclusion
Acknowledgment
References
2.
Intracellular RNA Sensing in Mammalian Cells: Role in Stress Response
and Cancer Therapies
1. Introduction
2. Overview of RNA Sensing Systems in Mammalian Cells
3. Discrimination of Self From Non-Self RNA. RNA Stress as an Aberrant
Recognition of Self-RNAs
4. Endogenous Ligands of RNA Sensors as Stress-Induced DAMPs
5. Epigenetic Silencing and Chromatin Conformation in Regulation of RNA
DAMPs
6. Intercellular and Intracellular Redistribution of RNA DAMPs
7.
Stress Granules, P-Bodies, and PML Nuclear Bodies as Cellular Compartments of
RNA Stress Response and IFN Signaling
8. Relationships Between RNA-Dependent and DNA-Dependent Pathways in
Tumor and Host immune Cells
9. Role of RNA Sensors in Conventional Therapy and Immunotherapy of
Cancer
10. Concluding Remarks and Future Directions
Acknowledgments
References
3.
Negative Regulation of Cytosolic Sensing of DNA
1. Introduction
2. Candidate Sensors of Intracellular DNA
3. DNA Sensing via the cGAS/STING Pathway
4. Regulation of cGAS/STING Dependent Signaling
5. Auto-Inflammatory Responses Mediated by cGAS/STING
6. Viral Strategies to Modulate cGAS/STING Function
7. Modulation of Innate Immune Response by NLRs
8. NLRP14: A New Rheostat of Cytosolic Nucleic Acid Sensing
9. Concluding Remarks
Acknowledgments
References
4.
Nucleic Acid Sensing Perturbation: How Aberrant Recognition of
Self-Nucleic Acids May Contribute to Autoimmune and Autoinflammatory Diseases
1. Introduction
2. Principles of Nucleic Acid Sensing
3. The Nucleic Acid Receptors
4. Innate Immune Detection of Microbial Nucleic Acids
5. Nucleic Acid Sensing by TLRs of the PRR Family in Distinct Cellular
Compartments
6. Can Sequence Patterns Influence Recognition?
7. Regulation of DNA Sensing
8. TLRs and Autoimmunity
9. Commensals: A Potent Player in Immunity
10. Do Microbes Have a Role in Autoimmunity?
11. Gut Microbiota and Autoimmunity: The Future
12. Methods
References
5.
Common Differences: The Ability of Inflammasomes to Distinguish Between
Self and Pathogen Nucleic Acids During Infection
1. Introduction
2. Overview of the AIM2 Inflammasome
3. NLRP3: The Omniscient Inflammasome
4. The IFI16 Inflammasome
5. NLRP9b: The Newest Nucleic Acid Sensing Inflammasome
6. Nucleic Acid Sensing Inflammasomes in Autoinflammation and
Autoimmunity
7. Conclusions
Acknowledgments
References
6.
Activating the Nucleic Acid-Sensing Machinery for Anticancer Immunity
1. Introduction
2. Overview of Nucleic Acid Sensors
3. DNA Sensing in Tumorigenesis Versus Treatment
4. Exogenous Activation by Administration of Ligands
5. Endogenous Nucleic Acid Sensor Activation by Host Ligands
6. Does Cancer Have a Particular Tendency to Activate Nucleic Acid
Sensors?
7. Role of DNA Damaging Agents in Cancer Treatment
8. Conclusions
Funding
References
7.
Cytosolic Nucleic Acid Sensors in Inflammatory and Autoimmune Disorders
1. Introduction
2. The cGAS-STING Pathway
3. The RNA Sensor RIG-I-Like Receptors (RLRs)
4. The DNA Sensor AIM2
5. DNA Sensor IFI16
6. Additional Cytoplasmic Nucleic Acid Sensors
7. Conclusion
Acknowledgement
References
