Parkinson's disease / edited by Kailash P. Bhatia, K. Ray Chaudhuri, Maria Stamelou. -- Cambridge, MA : Academic Press, c2017 .—(59.59 /P526 /v.132)

Contents

Contributors

Preface

1. Hallmarks of Clinical Aspects of Parkinson's Disease Through Centuries

1.  Introduction

2.  Introduction of Levodopa and New Motor Features

3.  Concluding Remarks

References

2. The Motor Syndrome of Parkinson's Disease

     1.  Introduction

       2.  Motor Symptoms of PD

       3.  Summa~

       References

3. The Nonmotor Features of Parkinson's Disease

      1.  Impact of Nonmotor Symptoms on Quality of Life in Parkinson's Disease

      2.  PD Is a Nonmotor and Motor Disorder: Aspects of Pathophysiology

      3.  Nonmotor Symptoms in PD: The Clinical Aspects

      4.  Nonmotor Symptoms and Gender Association

      5.  Classification of Nonmotor Symptoms of PD

      6.  Nonmotor Symptoms Measurement in Clinics

      7.  Nonmotor Fluctuations

      8.  Biomarkers

      9.  Treatment of Nonmotor Symptoms

      10.  Nonmotor Subtyping of Parkinson's

      11.  Multidisciplinary Care and Nonmotor Symptoms of PD

      12.  Drug-Induced Nonmotor Symptoms of PD

      13.  Conclusions

      References

4. The New Diagnostic Criteria for Parkinson's Disease

      1.  Parkinson's Disease Diagnosis: How Accurate Are We?

      2.  Prior Diagnostic Criteria

      3.  Rationale for New Criteria

      4.  Underlying Assumptions of MDS Criteria: Definition of PD

      5.  Clinical Diagnostic Criteria: Overall Design

      6.  Negative Criteria

      7.  Absolute Exclusions

      8.  Red Flags

      9.  The MDS Prodromal Criteria

      10.  Conclusions

      References

5. Advances in the Clinical Differential Diagnosis of Parkinson's Disease

1.  Introduction

2.  Phenotypic Variability and Clinical Heterogeneity of Parkinson's Disease

3.  Differential Diagnosis of Parkinson's Disease

4.  Other Rarer Differential Diagnoses

5.  Summary

References

6. Clinical Assessments in Parkinson's Disease: Scales and Monitoring

       1.  Introduction

       2.  Measurement: Concepts and Need

       3.  PD as an Object for Measurement

       4.  Objective Measures for PD: The Rationales

       5.  Conclusion

       Acknowledgments

       References

7. Biomarkers of Parkinson's Disease: An Introduction

       1.  Introduction

       2.  The Types of Biomarkers

3.  Neuroimaging

4.  Neuroinflammation

5.  The Future

Acknowledgments

References

8. Genetics of Parkinson's Disease: Genotype-Phenotype Correlations

1.  Introduction

2.  Monogenic Forms With a Picture Largely Restricted to Parkinsonism

3.  Monogenic Forms With Additional Clinical Features

4.  Involvement of Genes Linked to the Dopamine Biosynthesis Pathway

5.  GWAS and Lowly Simple Case Control Association Studies

6.  Conclusion

References

9. Imaging in Parkinson's Disease

     1.  Idiopathic Parkinson's Disease: Introduction

     2.  Conclusions and Future Directions

      Acknowledgments

      References

10. Cerebrospinal Fluid Biomarkers of Cognitive Decline in Parkinson's Disease

1.  Introduction

2.  β-Amyloid 1-42

3.  t-Tau and p-Tau

4.  Total α-Syn and Oligomeric α-Syn

5.  Other CSF Biomarkers

6.  Lumbar Puncture Safety

7.  Conclusion.

References

11. Hallmarks of Treatment Aspects: Parkinson's Disease Throughout Centuries Including L-Dopa

       1.  Introduction

2.  Anticholinergics

3.  Amantadine

4.  Apomorphine

5.  L-Dope

6.  Dopamine Agonists

7.  CDS Strategy and Then Transition to CDD Strategy

References

12. Treatment Strategies in Early Parkinson's Disease

       1.  Introduction

       2.  Pharmacological Therapy

       3.  Nonpharmacological Therapies

       4.  Summary of the Guidelines Available

       References

13. Treatment of Nonmotor Symptoms in Parkinson's Disease

       1.  Introduction

       2.  Sleep Disturbances

       3.  Cognitive impairment

       4.  Depressive Symptoms and Anxiety

       5.  Orthostatic Hypotension

       6.  Urinary Dysfunction

       7.  Gastrointestinal Dysfunction

       8.  Nutrition and Parkinson's Disease

       9.  Conclusion: Nonmotor Subtype-Specific Treatment in Parkinson's Disease?

       References

14. Treatment of Older Parkinson's Disease

       1.  Introduction

       2.  Treatment Strategies for Older PD Patients

       3.  Conclusion

       References

15. New Symptomatic Treatments for the Management of Motor and Nonmotor Symptoms of Parkinson's Disease

1.  Introduction

2.  New Dopaminergic Approaches to the Treatment of Motor Symptoms in PD

3.  New Nondopaminergic Approaches to the Treatment of Motor Symptoms in PD

4.  New Therapeutic Targets for the Treatment of Nonmotor Symptoms in PD

References

16. Device-Aided Treatment Strategies in Advanced Parkinson's Disease

1.  Introduction

2.  Deep Brain Stimulation

3.  Levodopa-Carbidopa Intestinal Gel

4.  Continuous Subcutaneous Apomorphine Infusion

5.  Conclusions

References

17. Palliative Care for Patients and Families With Parkinson's Disease

       1.  Parkinson's Disease

       2. Traditional Therapeutic Approaches

       3.  Gaps in Therapeutic Approaches

       4.  Concept of Palliative Care

       5.  Clinical Trials in Palliative Care

       6.  Misconceptions Associated With Palliative Care

       7.  Concept of Palliative Care in Neurodegenerative Diseases

       8.  Palliative Care as Part of Therapeutic Interventions in PD

       9.  Addressing Symptom Burden in Advanced-PD: Outcomes and Measures

       10.  Implication for Clinical Practice and for Research

       11.  Conclusion

       References

18. Multidisciplinary Care in Parkinson's Disease

       1.  Introduction

       2.  Current Approach to Parkinson's Disease Care

       3.  Limitations and Barriers

       4.  Future of MDTs in Parkinson's Disease

       References