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Human stem cell toxicology / edited by James L. Sherley, Asymmetrex, LLC, Boston, MA, USA. -- Cambridge, UK : Royal Society of Chemistry, 2016. – (58.155/H918s) |
Contents
Chapter 1
Addressing Challenges to Progress in Human Stem Cell Toxicology Concepts
and Practice
1.1
Filling in the Stem Cell Gap in Human Toxicology
1.2
Historical Impact of the Hierarchical, Anatomical, Sub-disciplinary
Structure of Toxicological Sciences
1.3
Human Stem Cell Toxicology as a Stem Cell Exact Science
1.4
Health and Medical Applications for Human Stem Cell Toxicological
Sciences
1.5
Introducing the Future Diverse Impacts of Human Stem Cell Toxicology
Acknowledgements
References
Chapter 2
Alternative Methods in Haematopoietic Stem Cell Toxicology
2.1
Introduction
2.2
Haematopoietic Stem Cell Toxicity or Hematotoxicity
2.3
Colonogenic Assays as Predictors of Haematopoietic Stem Cell Toxicity
2.4
Conclusions
Acknowledgements
References
Chapter 3
High-throughput Screening of Toxic Chemicals on Neural Stem Cells
3.1
Neural Stem Ceils
3.2
Toxic Chemicals in the Environment
3.3
Mechanisms of Neural Stem Cell Toxicity
3.4
NSC Differentiation
3.5
Conventional In vitro Assays for Toxicity Screening against Neural Stem
Cells
3.6
Challenges of Conventional In vitro Approaches in Neurotoxicity
Screening
3.7
Conclusions and Future Directions
Acknowledgements
References
Chapter 4
The Role of Catecholamines in Stem Cell Mobilisation
4.1
Introduction
4.2 Catecholamines
4.3
Catecholamines and Stem Cell Mobilisation
4.4
Consequences of Catecholamine-modulating Agents for Stem Cell Toxicity
4.5
Concluding Comments
References
Chapter 5
Toxicological Risk Assessment - Proposed Assay Platform Using Stem and Progenitor
Cell Differentiation in Response to Environmental Toxicants
5.1
Introduction
5.2
Environmental Toxicological Risk Assessment Employing an Assay Platform
That Uses Stem and Progenitor Cell Differentiation
5.3
Current State of ECF Platform Development
5.4
Bioanalytical Method Validation
5.5
Final Thoughts
References
Chapter 6
Current Developments in the Use of Human Stem Cell Derived
Cardiomyocytes to Examine Drug-induced Cardiotoxicity
6.1
Introduction
6.2
Constraints Due to Species Differences
6.3
Stem Cells and iPSC-CMs
6.4
Limitations with Stem Cells
6.5
Stem Cells in Cardiovascular Safety Pharmacology
6.6
Disease Models Based on iPSC-CMs
6.7
Generation of iPSC-CMs - Considerations on Differentiation, Maturity,
Heterogeneity and Purification Protocols
6.8
Use of iPSC-CMs in Phenotypic Assays
6.9 Assay Technologies Incorporating iPSC-CMs and
hESC-CMs
6.10
CiPA: Comprehensive In vitro Proarrhythmia Assay
6.11
Conclusion
References
Chapter 7
Pesticides and Hematopoietic Stem Cells
7.1
Pesticide Toxicity-induced Disorders of Hematopoietic System
7.2
Pesticide Toxicity on Hematopoietic Stem Cells and their
Microenvironment
7.3
Experimental Medicine Against Pesticide Toxicity-induced Hematopoietic
Failure
7.4
Future Direction
References
Chapter 8
Epigenetic Impact of Stem Cell Toxicants
8.1
Introduction
8.2
Epigenetic Regulation of Stem Cells
8.3
Stem Cell Toxicants as Modulators of Epigenetic Programming
8.4
Conclusion
Acknowledgements
References
Chapter 9
Metakaryotic Cancer Stem Cells are Constitutively Resistant to X-Rays
and Chemotherapeutic Agents, but Sensitive to Many Common Drugs
9.1
Introduction
9.2
Materials and Methods
9.3
Results
9.4
Discussion
Acknowledgements
References
Chapter 10 Distributed Stem Cell Kinetotoxicity:
A New Concept to Account for the Human Carcinogenicity of Non-genotoxie
Environmental Toxicants
10.1
Introduction
10.2
Results and Discussion
10.3
Conclusions and Closing Thoughts
10.4
Materials and Methods
Acknowledgements
References
Chapter 11 Cancer Stem Cells as Therapeutic
Targets
11.1
Introduction
11.2
CSC Markers and Therapeutic Targets
11.3
Signal Transduction in CSCs and Targeted Agents
11.4
Asymmetric Cell Divisions: The Dilemma of Studies on CSCs
11.5
Asymmetric Cell Divisions: Visualization of CSCs and Toxicology
11.6
Asymmetric Cell Divisions; Potential Therapeutics Targeting CSCs
11.7
Closing Remarks
Acknowledgements
References
Subject Index
