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Introductory biostatistics / Chap T. Le, Lynn E. Eberly. -- Second edition. -- Hoboken, New Jersey : John Wiley & Sons, Inc., 2016. – (58.1057 /L433 /2nd ed.)

Contents

Preface to the Second Edition

Preface to the First Edition

About the Companion Website

1  Descriptive Methods for Categorical Data

1.1  Proportions

1.2 Rates

1.3 Ratios

1.4 Notes on Computations

Exercises

2  Descriptive Methods for Continuous Data

2.1 Tabular and Graphical Methods

2.2 Numerical Methods

2.3 Special Case of Binary Data

2.4 Coefficients of Correlation

2.5 Notes on Computations

Exercises

3  Probability and Probability Models

3.1 Probability

3.2 Normal Distribution

3.3 Probability Models for Continuous Data

3.4 Probability Models for Discrete Data

3.5 Brief Notes on the Fundamentals

3.6 Notes on Computations

Exercises

4  Estimation of Parameters

4.1 Basic Concepts

4.2 Estimation of Means

4.3 Estimation of Proportions

4.4 Estimation of Odds Ratios

4.5 Estimation of Correlation Coefficients

4.6 Brief Notes on the Fundamentals

4.7 Notes on Computations

Exercises

5  Introduction to Statistical Tests of Significance

5.1 Basic Concepts

5.2 Analogies

5.3 Summaries and Conclusions

5.4 Brief Notes on the Fundamentals

Exercises

6  Comparison of Population Proportions

6.1 One-Sample Problem with Binary Data

6.2 Analysis of Pair-Matched Data

6.3 Comparison of Two Proportions

6.4 Mantel-Haenszel Method

6.5 Inferences for General Two-Way Tables

6.6 Fisher's Exact Test

6.7 Ordered 2 x K Contingency Tables

6.8 Notes on Computations

Exercises

7  Comparison of Population Means

7.1  One-Sample Problem with Continuous Data

7.2 Analysis of Pair-Matched Data

7.3 Comparison of Two Means

7.4 Nonparametric Methods

7.5 One-Way Analysis of Variance

7.6  Brief Notes on the Fundamentals

7.7  Notes on Computations

Exercises

8  Analysis of Variance

8.1  Factorial Studies

8.2  Block Designs

8.3  Diagnostics

Exercises

9  Regression Analysis

9.1  Simple Regression Analysis

9.2  Multiple Regression Analysis

9.3  Graphical and Computational Aids

10  Logistic Regression

10.1 Simple Regression Analysis

10.2  Multiple Regression Analysis

10.3  Brief Notes on the Fundamentals

10.4 Notes on Computing

Exercises

ll  Methods for Count Data

11.1  Poisson Distribution

11.2 Testing Goodness of Fit

11.3  Poisson Regression Model

Exercises

12  Methods for Repeatedly Measured Responses

12.1  Extending Regression Methods Beyond Independent Data

12.2  Continuous Responses

12.3 Binary Responses

12.4  Count Responses

12.5  Computational Notes

Exercises

13  Analysis of Survival Data and Data from Matched Studies

13.1  Survival Data

13.2 Introductory Survival Analyses

13.3   Simple Regression and Correlation

13.4   Multiple Regression and Correlation

13.5   Pair-Matched Case-Control Studies

13.6   Multiple Matching

13.7   Conditional Logistic Regression

Exercises

14  Study Designs

14.1   Types of Study Designs

14.2   Classification of Clinical Trials

14.3   Designing Phase I Cancer Trials

14.4   Sample Size Determination for Phase II Trials and Surveys

14.5   Sample Sizes for Other Phase II Trials

14.6   About Simon's Two-Stage Phase II Design

14.7   Phase II Designs for Selection

14.8   Toxicity Monitoring in Phase II Trials

14.9   Sample Size Determination for Phase III Trials

14.10  Sample Size Determination for Case-Control Studies

Exercises

References

Appendices

Answers to Selected Exercises

Index