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Progress in molecular biology and translational science. Volume 129, The molecular basis of viral infection / edited by P. J. Klasse. -- Amsterdam : Academic Press, 2015. – (58.178/P964/v.129) |
Contents
Contributors
Preface
1. Unity in
Diversity: Shared Mechanism of Entry Among Paramyxoviruses
1. Introduction to
Paramyxoviruses
2. Structure and
Function of the Paramyxovirus Glycoproteins
3. Proposed
Mechanisms of Receptor-Binding Protein and Fusion Protein Interactions
4. Conclusions
Acknowledgments
References
2. Alphavirus
Entry into Host Cells
1. Introduction
2. Alphavirus
Interaction with Host Cells
3. Measuring Viral
Entry
4. Alphavirus
Genome Delivery
5. Alphavirus
Entry in the Absence of Membrane Fusion
6. Challenges and
Perspectives
Acknowledgments
References
3. The Mechanism
of HCV Entry into Host Cells
1. Introduction
2. The Viral
Particle Organization and Composition: A Fundamenta Key to Decrypt Virus Entry
3. Early Steps of
Virus Entry
4. Receptor
Binding and Clustering
5. Postbinding
Steps and Virus Fusion
6. Concluding
Remarks
Acknowledgments
References
4. The Evolution
of HIV-1 Interactions with Coreceptors and Mannose C-Type Lectin Receptors
1. Introduction
2. Chemokine
Receptors as Critical HIV-1 Coreceptors
3. Evolution of
Coreceptor Use During Virus Transmission and Establishment in the New Host
4. Intrapatient
Evolution of HIV 1 Coreceptor Use
5. The Switch
Pathway
6. The
CCR5-Restricted Pathway
7. CLRs in HIV-1
Infection
8. CLRs and HIV-1
Interactions During Virus Transmission
9. CLRs and HIV-1
Interactions During the Chronic Infection Phase
10. Clinical
Aspects of Virus Evolution at the Interface of Coreceptors and Mannose CLR
Acknowledgments
References
5. A Game of
Numbers: The Stoichiometry of Antibody-Mediated Neutralization of Flavivirus
Infection
1. Introduction
2. Flavivirus
Structure
3. A Multiple-Hit
Model for the Neutralization of Flaviviruses
4. The
Stoichiometry of Neutralization and Enhancement of Flaviviruses
5. Factors That
Modulate the Stoichiometry of Neutralization
6. The
Stoichiometry of ADE
7. Insights into
Vaccines and Therapeutics
Acknowledgments
References
6.
TRIM21-Dependent Intracellular Antibody Neutralization of Virus Infection
1. Introduction
2. The Tripartite
Motif Family
3. TRIM21 is a
High-Affinity Cytosolic Fc Receptor
4. TRIM21 Mediates
Antibody-Dependent Intracellular Neutralization
5. TRIM21 is a
Sensor for Cytoplasmic Antibody
6. TRIM21
Functions are Ubiquitin Dependent
7. In Vivo
Relevance
8. Viral
Determinants of TRIM21-Mediated Neutralization
9. TRIM21 Exerts
Highly Efficient Incremental Neutralization
10. The Persistent
Fraction
11. Comparison of
TRIM21 with TRIM5cc
12. Conclusions
Acknowledgments
References
7.
Picornavirus-Host Interactions to Construct Viral Secretory Membranes
1. Back on the
Radar
2. Getting to 3A
3. GBF1
4. PI4KB
5. ACBD3
6. Cholesterol
7. 2B-2C Pore
Forming With ER-Golgi Membranes
8. Next Steps
9. Conclusion
Acknowledgments
References
8. Retroviral
Factors Promoting Infectivity
1. Introduction
2. Retroviral
Auxiliary Factors that Promote Infectivity
3. Retrovirus
Factors that Promote Virion Infectivity with a Yet Unknown Mechanism: 4. The
Nef and glycoGag Enigma
Final Remarks
References
9. The Cytoplasmic
Tail of Retroviral Envelope Glycoproteins
1. Introduction
2. Retroviral
Assembly
3. Synthesis and
Function of Env
4. Function of the
Retroviral Env CT
5. Conclusions
Acknowledgments
References
10. Molecular
Determinants of the Ratio of Inert to Infectious Virus Particles
1. Introduction: A
Wide Range of Particle-to-Infectious-Unit Ratio
2. Infectious or
Infecting?
3. Defective from the Start
4. Decay in
Suspension
5. Abortive
Infection
6. Conclusions
Acknowledgment
References
11. The Role of
Chance in Primate Lentiviral Infectivity: From Protomer to Host Organism
1. Introduction
2. Host Entry
3. Cell Entry
4. Synthesis and
Outlook
Acknowledgments
References
12. Virus-Encoded
7 Transmembrane Receptors
1. Evolutionary
Context of v7TMRs
2. Functional
Divergence from Cellular Chemokine Receptors
3. Biological
Roles of Viral CKRs
4. Concluding
Remarks
References
13. EBV, the Human
Host, and the 7TM Receptors: Defense or Offense?
1. EBV Infection
2. Immune Response
and Immune Evasion
3. EBV-BILF1 A Virus-Encoded 7TM Receptor with Immune
Evasive Functions
4. EBI2: An
Endogenous 7TM Receptor Manipulated by EBV
5. Manipulation of
the Host Immune System 7TM Receptors and Ligands by EBV The Chemokine System
6. EBV-Associated
Diseases
7. Drug Target
Potential
8. Conclusions
Acknowledgment
References
Index
