Membrane lipidomics for personalized health / Carla Ferreri, Chryssostomos Chatgilialoglu. -- Chichester, West Sussex : John Wiley and Sons, Inc., c2015. – (58.174236/F385)

Contents

About the Authors

Preface

Acknowledgments

Abbreviations

Part I  Molecular and Nutritional Basis of Cell Membranes and Lipidomics

1  Membranes for Life and Life for Membranes

1.1  Cell Membranes: The Role of Fatty Acids and the Exclusion of Trans Isomers

1.2  Organization and Homeostasis

      1a   In Depth: The Formation of a Cell Membrane

      1b   In Depth: Cholesterol and Membranes

      1c   Ill Depth: Lipid Rafts

2  Fatty Acid Families: Metabolism and Nutrition

2.1  Saturated Fatty Acids: Biosynthesis and Dietary Regulation

2.2  Monounsaturated Fatty Acids: The Importance to be cis

      2a   In Depth: The Key Steps of Phospholipid Synthesis

      2b   In Depth: Biosynthesis of the Double Bond and Desaturase Features

2.3  Polyunsaturated Fatty Acids: The Essentiality for Human Cells

Concepts' Summary

S1   Beware of the Nutritional Label!

S2   The Optimal Values of Fatty Acids in Tissues

S3   Structural Role of Fatty Acids

3  Essential Fatty Acids

3.1  The Omega-6 and Omega-3 Families: Cascades and Regulation

      3a   In Depth: The Definition of Omega-6 and Omega-3

      3b   The Polyunsaturated Fatty Acids in Cell Membrane Remodeling

      3c   In Depth: How do you Define an Inflammatory Pathway?

3.2  The Balance Between Omega-6 and Omega-3 Pathways: Nutritional and Metabolic Considerations

3.3  Food and Membranes: A Virtuous Cycle

4  Free Radicals and Lipids: Trans and Oxidized Fatty Acids

4.1  Trans Fatty Acids for Humans: The Nutritional Intake

4.2  Endogenous Sources of Trans Fatty Acids by Free Radical Stress

4.3  Free Radicals and Lipid Oxidation: The Threshold for Health

4.4  Lipoproteins and Development of Markers for Lipid Reactivity

          4a   In Depth: Oleic versus Linoleic Acid Reactivity with Free Radicals

Concepts' Summary

S1   Fatty Acid Geometry: A "Radical" Change

S2   Antioxidants for Membranes

Part II  Membrane Lipidomics for Personalized Health

What Is Lipidomics for Health

5.1  The Birth of the Postgenomics Era

5.2  Lipidomics in the Postgenomic Era

5.3  Fatty Acids Involved in Membrane and Mediator Lipidomics

5.4  Membrane Lipidomics: Cellular Stress, Turnover, and Opportunities

      5.4.1  How Does the Stress Involve Membranes?

5.5  Phospholipids From Dietary Intakes to Biological Functions

6  Lipidomics of Erythrocyte Membranes

6.1  Erythrocyte as a Comprehensive Health Biomarker

6.2  The Optimal Value Intervals and The Membrane Unbalance Index

6.3  Lipid Biosynthesis and Related Indices

6.4  The Individuation of Molecular Indicators

7  Nutrilipidomics

7.1  When Fatty Acids Become Nutraceuticals: Membrane Therapy With Nutrilipidomics

7.2  Fatty Acid-Based Membrane Lipidomics and Nutrilipidomics: The Personalized Approach for Nutrition and Nutraceuticals in Health and Diseases

8  Lipidomic Profiles and Intervention Strategies in Prevention and Diseases

8.1  Lipidomics and Sport

8.2  Lipidomics and Pregnancy

8.3  Lipidomics and Aging

8.4  Lipidomics and Cardiovascular Health

8.5  Lipidomics and Overweight

8.6  Lipidomics and Dermatology

8.7  Lipidomics and Neurology

8.8  Lipidomics and Ophtalmology

8.9  Conclusive Remarks

9  Lipidomics and Tutorials

9.1  First Steps for the Lipidomic Analysis

          9.1.1  Saturated Fatty Acid Excess

          9.1.2  Monounsaturated Fatty Acid Excess

          9.1.3  Omega-6 PUFA Excess

          9.1.4  Omega-3 PUFA Deficit

9.2  Learning Verification

References and Notes

Index