Computational neuroscience : simulated demyelinating neuropathies and neuronopathies / Diana Ivanova Stephanova, Bozhidar Dimitrov. -- Boca Raton : CRC Press, c2013. – (59.429 /S827) |
Contents
CONTENTS
NERVE FIBRES: Myelinated Axons
Demyelinating Neuropathies
Neuronopathies
Axonal Excitability
Mathematical Modeling of the Nerve Fibres
MODELS AND METHODS FOR INVESTIGATION OF THE HUMAN MOTOR NERVE FIBRE: Multi-Layered and Double Cable Models
Line-Source Model
Methods of Stimulation and Calculation of the Potentials
Methods for Calculation of the Strength-Duration Time
Constants, Rheobasic Currents and Recovery Cycles
SIMULATED DEMYELINATING NEUROPATHIES AND NEURONOPATHIES: Simulation of CMT1A, CIDP, Subtypes CIDP, GBS, MMN, and ALS
Abnormalities in the Potentials Action Potentials
Electrotonic Potentials
Abnormalities in the Extracellular Potentials and their Mechanisms
Abnormalities in the Strength-Duration Time Constants, Rheobasic Currents and Their Mechanisms
Abnormalities in the Recovery Cycles and Their Mechanisms
EFFECT OF THE MYELIN SHEATH AQUEOUS LAYERS ON THE EXCITABILITY PROPERTIES OF THE SIMULATED HEREDITARY AND CHRONIC DEMYELINATING NEUROPATHIES: Simulation of the CMT1A, CIDP and Subtypes CIDP with Aqueous Layers within the Myelin Sheath
Effect of the Myelin Sheath Aqueous Layers on the Potentials
Effect of the Myelin Sheath Aqueous Layers on the Strength-Duration Time Constants, Rheobasic Currents and Recovery Cycles
References