Chemical biology : approaches to drug discovery and development to targeting disease / edited by Natanya Civjan. -- Hoboken, N.J. : Wiley, c2012. – (58.173/C517a)

Contents

    Table Of Contents:
    
    Preface ix
    Contributors xi
    PART I DRUG DISCOVERY AND DEVELOPMENT 1(202)
    1 The Role of Chemical Biology in Drug Discovery 3(20)
    2 Computational Approaches to Drug Discovery and Development 23(18)
    3 Design and Selection of Small Molecule Inhibitors 41(24)
    4 Lead Optimization in Drug Discovery 65(18)
    5 Pharmacokinetics of Drug Candidates 83(18)
    6 ADME Properties of Drugs 101(14)
    7 Drug Transport in Living Systems 115(18)
    8 Blood-Brain Barrier: Considerations in Drug Development and Delivery 133(14)
    9 Pharmacokinetic Considerations: Methods and Systems of Controlled Drug Delivery 147(18)
    10 Pharmaceuticals: Natural Products and Natural Product Models 165(38)
    11 The Role of Chemical Biology in Understanding and Treating Disease---Are Small Molecule "Correctors" the Way of the Future? 205(10)
    12 Anxiety Disorders 215(30)
    13 Chronic Obstructive Pulmonary Disease (COPD) 245(22)
    14 Depression 267(26)
    15 Osteoarthritis 293(38)
    16 Human Immunodeficiency Virus (HIV) 331(10)
    17 Allergy and Asthma 341(16)
    18 Schizophrenia 357(22)
    19 Protein Misfolding and Disease 379(22)
    20 Protein Trafficking Diseases 401(18)
    21 Metabolic Diseases 419(26)
    22 Mitochondrial Medicine 445(16)
    23 Lysosomal Disorders 461(22)
    Index 483