Protein oxidation and aging / by Tilman Grune, Betul Catalgol, Tobias Jung. -- Hoboken, N.J. : John Wiley & Sons, c2013. – (58.17421/G891)

Contents

    CONTENTS
    
    Introduction to the Wiley Series on Protein and Peptide Science xi
    Preface xiii
    1 Oxidative Stress and Protein Oxidation 1
    1.1 The Large Variety of Protein Oxidation Products， 7
    1.2 Reversible Oxidative Modifi cations， 55
    1.3 Irreversible Oxidation Products， 64
    1.4 The Oxidation of Extracellular Matrix， Membrane and Cytoskeletal Proteins， 83
    1.5 Mechanism and Factors Influencing the Formation of Protein Oxidation Products， 100
    1.6 Protein Aggregates: Formation and Specific Metabolic Effects， 111
    1.7 Methods to Measure Protein Oxidation Products in Research Laboratories， 119
    References， 139
    2 Removal of Oxidized Proteins 215
    2.1 The Limited Repair of Some Oxidized Proteins， 216
    2.2 Proteolysis， 221
    2.3 The Role of Other Proteases in the Fate of Oxidized Proteins， 254
    2.4 Role of Heat Shock Proteins in Protein Degradation， 260
    2.5 Conclusion， 262
    References， 262
    3 Protein Oxidation and Aging: Different Model Systems and Affecting Factors 295
    3.1 Protein Oxidation during Aging: Lower Organisms and Cellular Model Systems， 297
    3.2 Nonmammalian Model Systems and the Accumulation of Oxidized Proteins during Aging， 308
    3.3 Age-Related Protein Oxidation in Humans and Mammals， 317
    3.4 Inherited Factors Influencing Protein Oxidation during Aging， 331
    3.5 Age-Related Protein Aggregate Formation in Model Systems， 341
    3.6 Environmental Factors Affecting Healthy Aging， 342
    3.7 Repair and Degradation of Oxidized Proteins during Aging， 370
    References， 372
    4 Protein Oxidation in Some Age-Related Diseases 417
    4.1 Protein Oxidation during Neurodegeneration and Neurological Diseases， 417
    4.2 Protein Oxidation in Cardiac Diseases， 429
    4.3 Protein Oxidation in Diabetes， 431
    4.4 Protein Oxidation in Degenerative Arthritis， 434
    4.5 Protein Oxidation in Muscle Wasting and Sarcopenia， 435
    4.6 Protein Oxidation in Destructive Eye Diseases， 437
    4.7 Protein Oxidation in Osteoporosis， 440
    4.8 Protein Oxidation in Cancer， 441
    4.9 Other Diseases， 446
    References， 448
    List of Abbreviations 479
    Index 493