Chemical genomics / edited by Haian Fu. — Cambridge ; New York : Cambridge University Press, 2012. – (58.1481/C517c)

Contents

    CONTENTS
    
    LIST OF CONTRIBUTORS vii
    PREFACE xi
    SECTION ONE OVERVIEWS
    1. HARNESSING THE POWER OF CHEMISTRY FOR BIOLOGYAND MEDICINE 3
    2. EXPLORING BIOLOGY WITH SMALL ORGANIC MOLECULES 10
    3. CHEMICAL PROTEOMICS: A GLOBAL STUDY OF PROTEIN-SMALL MOLECULE INTERACTIONS 26
    SECTION TWO MOLECULES FOR CHEMICAL GENOMICS
    4. DIVERSITY-ORIENTED SYNTHESIS 39
    5. TARGETED CHEMICAL LIBRARIES 60
    6. FRAGMENT-BASED LIGAND DISCOVERY
    7. BASICS AND PRINCIPLES FOR BUILDING NATURAL PRODUCT-BASED LIBRARIES FOR HTS 87
    SECTION TIIREE BASICS OF HIGH-THROUGHPUT SCREENING
    8. ESSENTIALS FOR HIGH-THROUGHPUT SCREENING OPERATIONS 101
    9. HIGH-CONTENT ANALYSIS AND SCREENING: BASICS， INSTRUMENTATION， AND APPLICATIONS 108
    10. PHENOTYPIC SCREENS WITH MODEL ORGANISMS 121
    11. SCREENING INFORMATICS AND CHEMINFORMATICS 137
    SECTION FOUR CHEMICAL GENOMICS ASSAYS AND SCREENS
    12. BASICS OF HTS ASSAY DESIGN AND OPTIMIZATION 159
    13. MOLECULAR SENSORS FOR TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL ASSAYS 173
    14. TIME-RESOLVED FLUORESCENCE RESONANCE ENERGY TRANSFER TECHNOLOGIES IN HTS 198
    15. COMPOUND PROFILING WITH HIGH-CONTENT SCREENING METHODOLOGY 215
    16. USE OF TRANSGENIC ZEBRAFISH IN A PHENOTYPIC SCREEN FOR ANGIOGENESIS INHIBITORS 225
    17. FLOW CYTOMETRY MULTIPLEXED SCREENING METHODOLOGIES 232
    18. LABEL-FREE BIOSENSOR TECHNOLOGIES IN SMALL MOLECULE MODULATOR DISCOVERY 245
    19. BASIC PRINCIPLES AND PRACTICES OF COMPUTER-MDED DRUG DESIGN 259
    20. COMPUTATIONAL APPROACH FOR DRUG TARGET IDENTIFICATION 279
    SECTION FIVE CHEMICAL GENOMICS AND MEDICINE
    21. PHARMACOGENOMICS TO LINK GENETIC BACKGROUND WITH THERAPEUTIC EFFICACY AND SAFETY 293
    22. DRUGS， GENOMIC RESPONSE SIGNATURES， AND CUSTOMIZED CANCER THERAPY 301
    23. CURRENT DRUG TARGETS AND THE DRUGGABLE GENOME 320
    INDEX 333