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Chemical genomics / edited by Haian Fu. — Cambridge ; New York : Cambridge University Press, 2012. – (58.1481/C517c) |
Contents
CONTENTS
LIST OF CONTRIBUTORS vii
PREFACE xi
SECTION ONE OVERVIEWS
1. HARNESSING THE POWER OF CHEMISTRY FOR BIOLOGYAND MEDICINE 3
2. EXPLORING BIOLOGY WITH SMALL ORGANIC MOLECULES 10
3. CHEMICAL PROTEOMICS: A GLOBAL STUDY OF PROTEIN-SMALL MOLECULE INTERACTIONS 26
SECTION TWO MOLECULES FOR CHEMICAL GENOMICS
4. DIVERSITY-ORIENTED SYNTHESIS 39
5. TARGETED CHEMICAL LIBRARIES 60
6. FRAGMENT-BASED LIGAND DISCOVERY
7. BASICS AND PRINCIPLES FOR BUILDING NATURAL PRODUCT-BASED LIBRARIES FOR HTS 87
SECTION TIIREE BASICS OF HIGH-THROUGHPUT SCREENING
8. ESSENTIALS FOR HIGH-THROUGHPUT SCREENING OPERATIONS 101
9. HIGH-CONTENT ANALYSIS AND SCREENING: BASICS, INSTRUMENTATION, AND APPLICATIONS 108
10. PHENOTYPIC SCREENS WITH MODEL ORGANISMS 121
11. SCREENING INFORMATICS AND CHEMINFORMATICS 137
SECTION FOUR CHEMICAL GENOMICS ASSAYS AND SCREENS
12. BASICS OF HTS ASSAY DESIGN AND OPTIMIZATION 159
13. MOLECULAR SENSORS FOR TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL ASSAYS 173
14. TIME-RESOLVED FLUORESCENCE RESONANCE ENERGY TRANSFER TECHNOLOGIES IN HTS 198
15. COMPOUND PROFILING WITH HIGH-CONTENT SCREENING METHODOLOGY 215
16. USE OF TRANSGENIC ZEBRAFISH IN A PHENOTYPIC SCREEN FOR ANGIOGENESIS INHIBITORS 225
17. FLOW CYTOMETRY MULTIPLEXED SCREENING METHODOLOGIES 232
18. LABEL-FREE BIOSENSOR TECHNOLOGIES IN SMALL MOLECULE MODULATOR DISCOVERY 245
19. BASIC PRINCIPLES AND PRACTICES OF COMPUTER-MDED DRUG DESIGN 259
20. COMPUTATIONAL APPROACH FOR DRUG TARGET IDENTIFICATION 279
SECTION FIVE CHEMICAL GENOMICS AND MEDICINE
21. PHARMACOGENOMICS TO LINK GENETIC BACKGROUND WITH THERAPEUTIC EFFICACY AND SAFETY 293
22. DRUGS, GENOMIC RESPONSE SIGNATURES, AND CUSTOMIZED CANCER THERAPY 301
23. CURRENT DRUG TARGETS AND THE DRUGGABLE GENOME 320
INDEX 333