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Advances in virus research. v. 80 / edited by Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy. — Amsterdam : Elsevier, c2011. – (58.679/A244/v.80) |
Contents
CONTENTS
Contributors
1. Mechanistic Intersections Between Picornavirus Translation and RNA Replication
I. Background
II. IRES-Dependent Translation and IRES-Transacting Factors
III. Viral Modification of Canonical and Noncanonica Translation Factors
IV. Important Aspects of RNA Replication
V. Important RNA Elements in RNA Replication
VI. Viral and Cellular Proteins Involved in RNA Replication
VII. Alteration of Host Cell Environment and Implications for Replication
VIII. The Switch from Viral Translation to Viral RNA Replication
Acknowledgments
References
2. Mycoviruses, RNA Silencing, and Viral RNA Recombination
I. Introduction
II. Overcoming Technical Challenges to Mycovirus Research
III. Antiviral Defense Mechanisms in Fungi
IV. Regulation of the Fungal Antivira[ RNA Silencing Response
V. RNA Silencing Contributes to Mycovirus RNA Recombination
VI. Concluding Remarks
References
3. Viruses and Metabolism: Alterations of Glucose and Glutamine Metabolism Mediated by Human Cytomegalovirus
I. The Warburg Effect and Cancer Cells
II. Human Cytomegalovirus
III. Glucose, Pyruvate, and Glutamine Metabolism in HCMV-Infected Cells
IV. How does HCMV Accomplish These Alterations in Glucose and Glutamine Metabolism so that Glucose can be Used for Fatty Acid Synthesis?
V. Conclusions and Discussion
References
4. Regulatory Roles of Protein Kinases in Cytomegalovirus Replication
I. Introduction
II. The Nature of Herpesviral Protein Kinases
III. CrossTalk Between Herpesviral and Cellular Protein Kinases
IV. Conclusions
V. Outlook for Antiviral Research
Acknowledgments
References
5. HIV Immune Evasion: Disruption of Antigen Presentation by the HIV Nef Protein
I. Introduction to HIV-] Pathogenesis
II. HIV-1 Nef
III. Candidate Host Factors that Partner with Nef
IV. Downmodulation of MHC-L Endocytic Mechanism
V. Downmodulation of MHC-I; Evidence for Targeting of Newly Synthesized Protein in the Secretory Pathway
VI. Summary
Acknowledgments
References
Index
Color plate section at the end of the book