Exploring immunology : concepts and evidence / Gordon MacPherson and Jon Austyn ; illustrations by Ruth Hammelehle. — Weinheim : Wiley-Blackwell, c2012. –(63.17/M172)

Contents

    Contents
    
    preface
    A Note to the Reader XIX
    Introduction 7
    1 Introduction 1
    2 Immune Responses 1
    3 Infection and Immunity 1
    3.1 Life in a Micro-Organism-Rich World 1
    3.2 Infectious Disease 2
    4 Immunopathology and Immunotherapy 2
    4.1 Immune-Mediated Disease 2
    4.2 The Challenge of Transplants， the Problem of Cancer
    4.3 Immunological Interventions in Disease 3
    4.4 Using Immunological Tools for Diagnosis 3
    5 Exploring Immunology 3
    The Immune System 5
    1.1 Introduction 5
    1.2 Host Defence Against Infection 5
    1.3 Anatomical Basis of Immunity 9
    1.4 Cellular Basis of Immunity 12
    1.5 Molecular Basis of Immunity 24
    1.6 Immune Responses and Disease 37
    2 Infection and Immunity 49
    2.1 Introduction 49
    2.2 Pathogens and Infectious Disease 49
    2.3 Host Defence Against Infection 57
    2.4 Infection and Immunity in Action 69
    2.5 Immunity and Vaccines 94
    3 Functional Anatomy of the Immune System 99
    3.1 Introduction 99
    3.2 Natural Barriers 99
    3.3 Functional Anatomy of Innate Immunity 103
    3.4 Functional Anatomy of Adaptive Immunity 111
    3.5 Development of Blood Cells and Organs of Immunity 126
    3.6 Stem Cell and Gene Therapy 130
    4 Innate Immunity 133
    4.1 Introduction 133
    4.2 Induction of Innate Immunity 133
    4.3 Tissue-Resident Cells of Innate Immunity 145
    4.4 Recruited Effectors of Innate Immunity 153
    4.5 Haematopoiesis and Myeloid Cells 169
    4.6 Vaccines and Adjuvants 171
    5 T Cell-Mediated Immunity 175
    5.1 Introduction 175
    5.2 Major Histocompatibility Complex (MHC) and Antigen Presentation 179
    5.3 T Lymphocyte Activation 191
    5.4 Effector and Memory Functions of T Cells in Infection 196
    5.5 T Cell Development and Selection 209
    5.6 Adoptive Cell Therapy 215
    6 Antibody-Mediated Immunity 217
    6.1 Introduction 217
    6.2 Antibody Structure and Function 218
    6.3 B Cell Responses 236
    6.4 B Cell Memory， Antibodies and Long-Term Resistance to Re-Infection 250
    6.5 B Cell Differentiation and Selection 252
    6.6 Therapeutic Antibodies 254
    7 Immunity， Disease and Therapy 259
    7.1 Introduction 259
    7.2 What are the Mechanisms of Tissue Damage Caused by the Immune System? 262
    7.3 Why Do We Make Harmful Immune Responses to Harmless Antigens? 268
    7.4 Immunopathology and Therapy in Action 278
    7.5 Transplantation Immunology 300
    7.6 Tumour Immunity 306
    7.7 Conclusions 310
    Answers to the Questions 313
    Further Study Questions 333
    Index 337