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Nutrition in epigenetics / edited by Mihai D. Niculescu, Paul Haggarty. — Ames, Iowa : Wiley-Blackwell, c2011. – (59.54/N976) |
Contents
Contents
1. Introduction 1
PART I: Fundamental Principles in Epigenetics
SECTION A: Epigenetic Mechanisms
2. DNA Methylation 13
3. Chromatin Modifications 47
4. Roles of RNAi and Other Micro-RNAs in the Regulation of Epigenetic Processes
5. Epigenetic Inheritance: Both Mitotic and Meiotic 87
SECTION B: Development Epigenetics
6. DevelopmentalEpigenetics: Roles in Embryonic Development 107
SECTION C: Epigenetic Mechanisms in Disease
7. Epigenetics, Nutrition, and Cancer 129
8. Metabolic Syndrome, Obesity, and Diabetes 145
9. Autoimmunity 165
10. Cardiovascular Diseases 173
PART lI: Nutritional Status and Specific Nutrients
SECTION A: Maternal Nutrition and Fetal Development
11. Maternal Nutrition and Developmental Outcomes 193
SECTION B: Role of Specific Nutrients
12. Folate, Vitamin B12, and Vitamin B6 211
13. Dietary Choline, Betaine, Methionine, and Epigenetic Mechanisms Influencing Brain Development 225
14. Epigenetic Regulation by Retinoids 241
15. We Are What We Eat: How Nutritional Compounds Such As Isoflavones Shape Our Epigenome 249
16. Isothiocyanates and Polyphenols 263
SECTION C: Macronutrient Intakes
17. The Effect of Maternal Macronutrient Intake on Phenotype Induction and Epigenetic Gene Regulation 275
SECTION D: Environmental Exposures
18. Epigenetic Manifestation of Environmental Exposures 289
SECTION E: Epidemiology of Nutritional Epigenetics
19. Epigenetics, Nutrition, and Reproduction: Short- and Long-Term Consequences
20. Nutrition, Epigenetics, and Cancer: An Epidemioiogical Perspective 329
Index 345