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Handbook of epigenetics : the new molecular and medical genetics / edited by Trygve Tollefsbol. — Amsterdam : Elsevier, c2011. – (58.1481/H236) |
Contents
CONTENTS
CONTRIBUTORS
PREFACE
CHAPTER 1 Epigenetics: The New Science of Genetics 1
SECTION I: Molecular Mechanisms of Epigenetics 7
CHAPTER 2 Mechanisms of DNA Methylation, Methyl-CpG Recognition, and Demethylation in Mammals
CHAPTER 3 Mechanisms of Histone Modifications 25
SECTION II: Additional Epigenetic Processes 47
CHAPTER 4 The Epigenetics of Non-coding RNA 49
CHAPTER 5 Prions and Prion-like Phenomena in Epigenetic Inheritance 63
CHAPTER 6 Chromosomal Position Effects and Gene Variegation: Impact in Pathologies
CHAPTER 7 Polycomb Mechanisms and Epigenetic Control of Gene Activity 107
SECTION III: Epigenetic Technology 123
CHAPTER 8 Analysis of Gene-specific DNA Methylation 125
CHAPTER 9 Methods for Assessing Genome-wide DNA Methylation 135
CHAPTER 10 Methylation of Lysine 9 of Histone H3: Role of Heterochromatin Modulation and Tumorigenesis 149
CHAPTER 11 Chromatin Modifications Distinguish Genomic Features and Physical Organization of the Nucleus 159
CHAPTER 12 Assessing Epigenetic Information 173
SECTION IV: Model Organisms of Epigenetics 183
CHAPTER 13 Epigenetics of Eukaryotic Microbes 185
CHAPTER 14 Drosophila Epigenetics 203
CHAPTER 15 Mouse Models of Epigenetic Inheritance 233
CHAPTER 16 Epigenetic Regulatory Mechanisms in Plants 251
SECTION V: Metabolism and Epigenetics 279
CHAPTER 17 Metabolic Regulation of DNA Methylation in Mammals 281
CHAPTER 18 Dietary and Metabolic Compounds Affecting Chromatin Dynamics/Remodeling 295
SECTION VI: Functions of Epigenetics 313
CHAPTER 19 Epigenetics, Stem Cells, and Cellular Differentiation 315
CHAPTER 20 Epigenetic Basis of Skeletal Muscle Regeneration 329
CHAPTER 21 Epigenetics of X Chromosome Inactivation 341
CHAPTER 22 Genomic Imprinting 353
CHAPTER 23 Epigenetics of Memory Processes 381
CHAPTER 24 Transgenerational Epigenetics 391
CHAPTER 25 Aging Epigenetics 405
SECTION VII: Evolutionary Epigenetics 423
CHAPTER 26 Epigenetics in Adaptive Evolution and Development: The Interplay Between Evolving Species and Epigenetic Mechanisms 425
SECTION VIII: Epigenetic Epidemiology 447
CHAPTER 27 The Effects of Diet on Epigenetic Processes 449
CHAPTER 28 Environmental Agents and Epigenetics 459
CHAPTER 29 Impact of Microbial Infections on the Human Epigenome and Carcinogenesis
CHAPTER 30 DNA Methylation Profiles in the 5'-Upstream Region of the Human FMR1 Promoter and in an Adenovirus Transgenome 495
CHAPTER 31 Population Pharmacoepigenomics 511
SECTION IX: Epigenetics and Human Disease 519
CHAPTER 32 Cancer Epigenetics 521
CHAPTER 33 The Role of Epigenetics in Immune Disorders 535
CHAPTER 34 Epigenetics of Brain Disorders 553
CHAPTER 35 Complex Metabolic Syndromes and Epigenetics 569
CHAPTER 36 Imprinting Disorders in Humans 581
SECTION X: Epigenetic Therapy 595
CHAPTER 37 Clinical Applications of Histone Deacetylase Inhibitors 597
INDEX 617
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