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RNA worlds : from lifes origins to diversity in gene regulation / edited by John F. Atkins, Raymond F. Gesteland, Thomas R. Cech. — Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, c2011. – (58.174251/R486n) |
Contents
Contents
Preface， vii
Foreword to the First Edition of The RNA World， ix
Prologue to the First Edition of The RNA World， x
The RNA Worlds in Context， 1
THE EARLY RNAWORLD
Setting the Stage: The History， Chemistry， and Geobiology behind RNA， 7
The Origins of the RNA World， 21
Getting Past the RNA World: The Initial Darwinian Ancestor， 43
The Origins of Cellular Life， 51
WHAT RNA CAN DO BY ITSELF
Riboswitches and the RNA World， 63
Riboswitches: Structures and Mechanisms， 79
Small Self-cleaving Ribozymes， 93
Group II Introns: Mobile Ribozymes that Invade DNA， 103
EXIT THE RNAWORLD: PROTEIN SYNTHESIS ON RIBOSOMES
The Roles of RNA in the Synthesis of Protein， 123
Evolution of Protein Synthesis from an RNA World， 141
The Ribosome: Some Hard Facts about Its Structure and Hot Air about Its Evolution
RNP-ZYMES: WHAT RNA CAN DO IN COLLABORATION WITH PROTEIN
Noncoding RNPs of Viral Origin， 165
Spliceosome Structure and Function， 181
Telomerase: An RNP Enzyme Synthesizes DNA， 205
RNA REGULATED GENE EXPRESSION
Bacterial Small RNA Regulators: Versatile Roles and Rapidly Evolving Variations
RNA in Defense: CRISPRs Protect Prokaryotes against Mobile Genetic Elements， 231
Ancestral Roles of Small RNAs: An Ago-Centric Perspective， 243
RNA Interference and Heterochromatin Assembly， 255
The X as Model for RNA's Niche in Epigenomic Regulation， 267
The Long Arm of Long Noncoding RNAs: Roles as Sensors Regulating Gene Transcriptional Programs， 279
TOOLS FOR RNA SCIENCE
Folding and Finding RNA Secondary Structure， 293
Predicting and Modeling RNA Architecture， 309
RNA Reactions One Molecule at a Time， 321
Aptamers and the RNA World， Past and Present， 333
In Vivo RNAi: Today and Tomorrow， 343
Index， 355
