RNA interference : application to drug discovery and challenges to pharmaceutical development / edited by Paul H. Johnson. — Oxford : Wiley, 2011. – (58.174251/R486t)

Contents

    CONTENTS
    
    CONTRIBUTORS
    PREFACE
    FOREWORD
    I BIOLOGY OF RNA INTERFERENCE
    1 RNA INTERFERENCE: WHAT IS IT?
    2 NUCLEIC ACIDS AS REGULATORY MOLECULES
    3 USE OF siRNA OLIGONUCLEOTIDES TO STUDY GENE FUNCTION
    4 GENOME SCANNING BY RNA INTERFERENCE
    II DEVELOPMENT OF siRNA FOR THERAPEUTIC APPLICATIONS
    5 DISCOVERY OF NEW siRNA DELIVERY AGENTS
    6 siRNA DELIVERY VEHICLES
    7 INTERFERON， CYTOKINE INDUCTION， AND OTHER POTENTIAL IN VIVO TOXICITIES
    8 APPLICATION OF RNA INTERFERENCE TO VIRAL DISEASES
    INDEX