Genetic epidemiology / edited by M. Dawn Teare. — New York ; London : Humana Press, c2011. – (58.17/M592/v.713)

Contents

    Contents
    
    PART I INTRODUCTION
    1 Molecular Genetics and Genetic Variation
    2 Terminology， Concepts， and Models in Genetic Epidemiology
    3 An Introduction to Epidemiology
    PART II -GENETIC LINKAGE MAPPING
    4 Genetic Distance and Markers Used in Linkage Mapping 43
    5 Approaches to Genetic Linkage Analysis
    PART III GENETIC MAPPING BY ASSOCIATION
    6 Fine-Scale Structure of the Genome and Markers Used in Association Mapping
    7 Genome-Wide Association Studies
    8 Candidate Gene Association Studies 105
    9 Family-Based Association Studies 119
    10 Genome Variation: A Review of Web Resources
    PART IV EMERGING THEMES
    11 Advanced Methods in Twin Studies 143
    12 Mendelian Randomisation: A Tool for Assessing Causality in Observational epidemiology 153
    13 Copy Number Variation
    14 Epigenetic Variation
    PART V CASE STUDIES
    15 Modeling the Effect of Susceptibility Factors (HLA and PTPN22) in Rheumatoid Arthritis 201
    16 Coronary Artery Disease: An Example Case Study 215
    17 The Genetic Epidemiology of Obesity: A Case Study 227
    Index 239