TNF pathophysiology : molecular and cellular mechanisms / volume editors, G. Kollias, P.P. Sfikakis. — Basel, Switzerland ; New York : Karger, c2010.

Contents

    Contents
    
    vii Preface
    1 Cellular Mechanisms of TNF Function in Models of Inflammation and Autoimmunity
    27 Transcriptional Control of the TNF Gene
    61 Posttranscriptional Regulation of TNF mRNA: A Paradigm of Signal-Dependent mRNA Utilization and Its Relevance to Pathology
    80 Role of TNF in Pathologies Induced by Nuclear Factor KB Deficiency
    94 Type I Interferon: A New Player in TNF Signaling
    105 T Cells as Sources and Targets of TNF: Implications for Immunity and Autoimmunity
    119 TNF-a: An Activator of CD4+FoxP3+TNFR2+ Regulatory T Cells
    135 TNF and Bone
    145 TNF-a and Obesity
    157 TNF in Host Resistance to Tuberculosis Infection
    180 The First Decade of Biologic TNF Antagonists in Clinical Practice: Lessons Learned， Unresolved Issues and Future Directions
    211 Author Index
    212 Subject Index