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Cell death / editors, Gerry Melino, David Vaux. — Oxford : Wiley-Blackwell, 2010. – (58.1574/C393q) |
Contents
Contents
Contributors
Preface
The Siren's Song: This Death That Makes Life Live
The Origin and Evolution of Programmed Cell Death
Cell Death in C. elegans
Caspases and Cell Death
The Apoptosome: The Executioner of Mitochondria-mediated Apoptosis
Caspases, Substrates and Sequential Activation
Dismantling the Apoptotic Cell
The BCL-2 Family Proteins Key Regulators and Effectors of Apoptosis
BH3-only Proteins
Mitochondrial Outer Membrane Permeabilization 90
Mitochondria Fusion and Fission 97
Death Receptors
Death Receptors at the Molecular Level Therapeutic Implications
Death Receptor-induced Necroptosis 127
Inhibitor of Apoptosis (IAP) and BIR-containing Proteins
Structures, Domains and Functions in Cell Death (DD, DED, CARD, PYD)
Structure and Function of IAP and Bcl-2 Proteins 156
Engulfment of Apoptotic Cells and its Physiological Roles
Autophagy 175
Autophagy in Nonmammalian Systems
Apoptosis: Regulatory Genes and Disease 197
Caspases in Inflammation and Immunity
Immunity, Granzymes and Cell Killing 223
P53 and Cell Death 230
Cornification of the Skin: A Non-apoptotic Cell Death Mechanism
Apoptosis: Inherited Disorders
From Reactive Oxygen and Nitrogen Species to Therapy
Microbial Inhibitors of Apoptosis
Drug Discovery in Apoptosis