Advances in immunology. v. 105 / edited by Frederick W. Alt. — Amsterdam : Elsevier, c2010. – (58.691/A244/v.105)

Contents

    CONTENTS
    
    Contributors
    1. Learning from Leprosy: Insight into the Human Innate Immune Response
    1. Leprosy as a Model
    2. Recognition of M. leprae by the Innate Immune System
    3. Phagocytosis of Mycobacteria
    4. Antimicrobial Activity
    5. Dendritic Cell Function in Leprosy
    Acknowledgments
    References
    2. The Immunological Functions of Saposins
    1. Introduction
    2. Saposins in Lysosomal Glycosphingolipid Degradation and Membrane Digestion
    3. Saposins Facilitate Lipid Presentation to CD1-Restricted T Lymphocytes
    4. SAPs Stimulate the Processing of Lipid Antigens by Lysosomal Glycosidases
    5. Saposins Disrupt Vesicles Released by Apoptotic Cells
    6. SAP-Like Proteins in Antimicrobial Defense
    7. Conclusions
    References
    3. OX40-OX40 Ligand Interaction in T-Cell-Mediated Immunity and Immunopathology
    1. Introduction
    2. Impact of the OX40 Costimulatory Signal in Immune Responses
    3. OX40 in the Function and Development of Regulatory T Cells
    4. OX40-OX40L Interaction in the Generation and Homeostasis of Memory T Cells
    5. The OX40 and OX40L Interaction in Disease
    6. Summary and Future Perspectives
    References
    4. The Family of IL-10-Secreting CD4+ T Cells
    1. Introduction: The Role of IL-IO in Controlling Inflammation
    2. IL-]O-Producing T Cells Induced In Vitro
    3. Naturally Present IL-]O-Secreting T Cells
    4. Concluding Remarks
    Acknowledgments
    References
    5. Artificial Engineering of Secondary Lymphoid Organs
    1. Introduction
    2. Lymphoid Structure and Elicitation of Immune Responses
    3. Organogenesis of Secondary Lymphoid Tissues
    4. Engineering Artificial Secondary Lymphoid Tissue
    5. Future Prospects
    6. Conclusion
    Acknowledgments
    References
    6. AID and Somatic Hypermutation
    1. Introduction
    2. AID， The Master Catalyst
    3. The Targeting Enigma
    4. Rogue Uracils
    5. Conclusion
    Acknowledgments
    References
    7. BCL6: Master Regulator of the Germinal Center Reaction and Key Oncogene in B Cell Lymphomagenesis
    1. Germinal Center: The Site of BCL6 Expression in B cells
    2. BCL6 and Its Function
    3. Regulation of BCL6
    4. Discovery of BCL6 Targets
    5. Cellular Pathways Regulated by BCL6
    6. BCL6 and Lymphomagenesis
    7. Conclusions
    References
    Index