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Clinical applications of mass spectrometry : methods and protocols / edited by Uttam Garg, Catherine A. Hammett-Stabler. — New York : Humana Press, c2010. – (58.17/M592/v.603) |
Contents
Contents
Preface
Contributors
1. The Evolution of Mass Spectrometry in the Clinical Laboratory
2. Measurement of Plasma/Serum Acylcarnitines Using Tandem Mass Spectrometry
3. Comprehensive Determination of Amino Acids for Diagnosis of Inborn Errors of Metabolism
4. Identification and Quantitation of Amphetamine， Methamphetamine， MDMA， Pseudoephedrine， and Ephedrine in Blood， Plasma， and Serum Using Gas Chromatography-Mass Spectrometry (GC/MS)
5 Quantification of Antidepressants Using Gas Chromatography-Mass Spectrometry
6. Quantitation of Argatroban in Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (UPLC-ESI-MS/MS)
7. Quantitation of Amobarbital， Butalbital， Pentobarbital， Phenobarbital， and Secobarbital in Urine， Serum， and Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS)
8. Quantitation of Benzodiazepines in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS)
9. LC-MS/MS Analysis of 13 Benzodiazepines and Metabolites in Urine， Serum， Plasma， and Meconium 89
10. Simultaneous Determination and Quantification of 12 Benzodiazepines in Serum or Whole Blood Using UPLC/MS/MS 107
11. Determination of Benzoic Acid in Serum or Plasma by Gas Chromatography-Mass Spectrometry (GC/MS) 121
12. Quantification of Busulfan in Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS) 129
13. Quantitation of Total 11-Nor-9-Carboxy-Delta 9-Tetrahydrocannabinol in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) 137
14. Quantitation of Cocaine， Benzoylecgonine， Ecgonine Methyl Ester， and Cocaethylene in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS)
15. Identification and Quantitation of Cocaine， Benzoylecgonine， and Cocaethylene in Blood， Serum， and Plasma Using Ultra-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry (UPLC-MS/MS)
16. Detection and Quantification of Cocaine and Benzoylecgonine in Meconium Using Solid Phase Extraction and UPLC/MS/MS 165
17. Diagnosis of Creatine Metabolism Disorders by Determining Creatine and Guanidinoacetate in Plasma and Urine 175
18. Broad Spectrum Drug Screening Using Electron-Ionization Gas Chromatography-Mass Spectrometry (EI-GCMS) 187
19. Broad Spectrum Drug Screening Using Liquid Chromatography-Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry 203
20. High Sensitivity Measurement of Estrone and Estradiol in Serum and Plasma Using LC-MS/MS 219
21. 3-Hydroxy-Fatty Acid Analysis by Gas Chromatography-Mass Spectrometry 229
22. Quantitation of Fentanyl in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) 245
23. Determination of Total Homocysteine in Plasma Using Liquid Chromatography Coupled to Tandem Mass Spectrometry (LC/MS/MS) 253
24. Quantitation of Homovanillic Acid (HVA) and Vanillylmandelic Acid (VMA) in Urine Using Gas Chromatography-Mass Spectrometry (GC/MS) 261
25. Quantitation of 17-OH-Progesterone (OHPG) for Diagnosis of Congenital Adrenal Hyperplasia (CAH) 271
26. Determination of Hydroxyurea in Serum or Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS) 279
27. Quantitation of Ibuprofen in Blood Using Gas Chromatography-Mass Spectrometry (GC-MS)
28. Quantitation of Indomethacin in Serum and Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS) 297
29. Quantitation of Iothalamate in Urine and Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS) 307
30. Identification and Quantitation of Ketamine in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS) 317
31. Measurement of Filter Paper Bloodspot Lead by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)
32. Multiplex Lysosomal Enzyme Activity Assay on Dried Blood Spots Using Tandem Mass Spectrometry 339
33. Gas Chromatography-Mass Spectrometry Method for the Determination of Methadone and 2-Ethylidene- 1，5-Dimethyl-3， 3- Diphenylpyrrolidine (EDDP) 351
34. Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS) Method for Monitoring Methotrexate in the Setting of Carboxypeptidase-G2 Therapy 359
35. Quantitation of Methylmalonic Acid in Serum or Plasma Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry 365
36. Quantitation of Methylmalonic Acid in Plasma Using Liquid Chromatography - Tandem Mass Spectrometry
37. Monitoring of Mycophenolate Acid in Serum or Plasma Using LC Tandem Mass Spectrometry 379
38. Quantitation of Nicotine， Its Metabolites， and Other Related Alkaloids in Urine， Serum， and Plasma Using LC-MS-MS 389
39. Quantitation of Opioids in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) 399
40. Quantitation of Morphine， Codeine， Hydrocodone， Hydromorphone， Oxycodone， Oxymorphone， and 6-Monoacetylmorphine (6-MAM) in Urine， Blood， Serum， or Plasma Using Liquid Chromatography with Tandem Mass Spectrometry Detection 411
41. Urine Organic Acid Analysis for Inherited Metabolic Disease Using Gas Chromatography-Mass Spectrometry
42. Identification of Urine Organic Acids for the Detection of Inborn Errors of Metabolism Using Urease and Gas Chromatography-Mass Spectrometry (GC-MS) 433
43. Quantitation of Orotic Acid in Urine Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry
44. Quantitation of Oxycodone in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS)
45. Quantitation of Phencyclidine (PCP) in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS)
46. Quantitation of Sirolimus Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS) 469
47. Quantitation of Tacrolimus in Whole Blood Using High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS-MS) 479
48. Analysis of Testosterone in Serum Using Mass Spectrometry 489
49. Determination of Tetrahydrozoline in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) 501
50. Quantitation of25-OH-Vitamin D (25OHD) Using Liquid Tandem Mass Spectrometry (LC-MS-MS) 509
51. Identification and Quantitation of Zolpidem in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS) 519
52. Identification and Quantitation of Zopiclone in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS) 527
Subject Index 535
