Advances in virus research. v. 74 / edited by Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy. — Amsterdam : Elsevier, c2009. – (58.679/A244/v.74)

Contents

    Contents
    
    1. Regulation of HIV-1 Alternative Rf4A Splicing and Its Role in Virus Replication
    I. Introduction
    II. HIV-1 Splicing Regulatory Elements
    III. Evidence for the Functional Importance of HIV-1 Splicing Regulatory Elements in Virus Replication
    IV. Strategies to Target HIV-1 Splicing with Antiviral Drugs
    V. Conclusions and Perspectives
    Acknowledgments
    References
    2. New Insights into Flavivirus Nonstructural Protein 5
    I. Introduction
    II. The Methyltransferase Domain
    III. The RNA-Dependent RNA Polymerase Domain
    IV. NS5 Interactions
    V. NS5 Phosphorylation
    VI. NS5 Localization
    VII. Emerging Roles for NS5 in Viral Pathogenesis
    VIII. Conclusions and Future Perspectives
    Acknowledgments
    References
    3. Replication of the Hepatitis Delta Virus RNA Genome
    I. Background
    II. Polymerase(s)
    III. Promoters and Priming
    IV. Pausing and Switching
    V. Replication in the Nucleus
    VI. Role(s) of the Delta Antigen
    VII. Host Factors
    VIII. Viroid Analogy
    IX. Conclusions and Outlook
    Acknowledgments
    References
    4. Recent Epidemiology of Tick-Borne Encephalitis: An Effect of Climate Change?
    I. Introduction
    II. Major Debatable Issues
    III. The Ranges of Main Tick Vectors: Are They Really Expanding?
    IV. Tick Abundance and TBE Virus Prevalence: Have They Changed?
    V. Tick Expansion to the Cities: Is It Related to Climate Change?
    VI. What Is Known About Newly Formed TBE loci?
    VII. Anthropurgic TBE loci: What Are the Principles of Their Formation?
    VIII. Since When Has TBE Morbidity Increased in the Cities?
    IX. What Are the Main Causes of Changes in Parameters of TBE Morbidity?
    X. Conclusions
    Acknowledgment
    References
    Index
    Color plate section at the end of the book