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Immunotoxicity testing : methods and protocols / edited by Rodney R. Dietert. — New York : Springer, 2010. – (58.17/M592/v.598) |
Contents
Contents
Preface
Contributors
PART I INTRODUCTION
1 Immunotoxicology Testing: Past and Future
PART II OVERVIEW AND HEALTH-RISK CONSIDEI~ITIONS
2 Developmental Immunotoxicity (DIT): Tile Why， When， and How of DIT Testing
3 An In Vivo Tiered Approach to Test Immunosensitization by Low Molecular Weight Compounds
4 Risk of Autoimmune Disease: Challenges for Immunotoxicity Testing
5 Markers of Inflammation
6 Evaluating Macrophages in Immunotoxicity Testing
PART III IMMUNOTOXICITY AND HOST RESISTANCE MODELS
7 Host Resistance Assays Including Bacterial Challenge Models
8 Viral Host Resistance Studies
9 Parasite Challenge as Host Resistance Models for Immunotoxicity Testing
10 Tumor Challenges in Immunotoxicity Testing
PART IV TESTING PROTOCOLS IN RODENTS AND OTHER LABORATORY ANIMALS
11 The T-Dependent Antibody Response to Keyhole Limpet Hemocyanin in Rodents
12 The Sheep Erythrocyte T-Dependent Antibody Response (TDAR)
13 The Delayed Type Hypersensitivity Assay Using Protein and Xenogeneic Cell Antigens
14 Tile Cytotoxic T Lymphocyte Assay for Evaluating Cell-Mediated Immune Function
15 NK Cell Assays in Immunotoxicity Testing
16 The Local Lymph Node Assay and Skin Sensitization Testing
17 Use of Contact Hypersensitivity in Immunotoxicity Testing
18 Evaluation of Apoptosis in Immunotoxicity Testing
19 Dendritic Cells in Immunotoxicity Testing
20 Evaluating Cytokines in Immunotoxicity Testing
21 Flow Cytometry in Preclinical Drug Development
22 Enhanced Histopathology Evaluation of Lymphoid Organs
23 Immunotoxicity Testing in Nonhuman Primates
PART V EVALUATION IN HUMANS
24 Fundamentals of Clinical Immunotoxicology
PART VI WILDLIFE TESTING
25 In Vivo Functional Tests for Assessing Immunotoxicity in Birds
PART VII IN VITRO ALTERNATIVES
26 In Vitro Testing for Direct Immunotoxicity: State of the Art
Index
