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Gene and cell therapy : therapeutic mechanisms and strategies / edited by Nancy Smyth Templeton. — 3rd ed. — Boca Raton, Fla. : CRC ; London : Taylor & Francis [distributor], c2009. – (63.499/G326/3rd ed.) |
Contents
Contents
Foreword
Preface
Editor
Contributors
PART I Delivery Systems and Therapeutic Strategies
Chapter 1 Retroviral Vectors for Cell and Gene Therapy 3
Chapter 2 Production of Retroviral Vectors: From the Producer Cell to the Final Product 17
Chapter 3 Adenovirus Vectors for Gene Therapy 39
Chapter 4 Modified Adenoviruses for Gene Therapy
Chapter 5 Helper-Dependent Adenoviral Vectors for Gene Therapy 87
Chapter 6 Adeno-Associated Virus and AAV Vectors for Gene Delivery 115
Chapter 7 Therapeutic Gene Transfer with Replication-Defective Herpes Simplex Viral Vectors 159
Chapter 8 Oncolytic Viruses for Treatment of Cancer 193
Chapter 9 Lentiviral Vectors 207
Chapter 10 Vaccinia Viral Vectors 245
Chapter 11 Baculovirus-Mediated Gene Transfer: An Emerging Universal Concept 263
Chapter 12 Bacterial Vector in Gene Therapy 293
Chapter 13 Redox-Responsive Polymer-Based Gene Delivery Systems 309
Chapter 14 Polymers and Dendrimers for Gene Delivery in Gene Therapy 321
Chapter 15 Receptor-Targeted Polyplexes for DNA and siRNA Delivery 341
Chapter 16 Electroporation of Plasmid-Based Vaccines and Therapeutics 363
Chapter 17 Magnetofection: Using Magnetic Particles and Magnetic Force to Enhance and to Target Nucleic Acid Delivery 379
Chapter 18 Biolistic and Other Needle-Free Delivery Systems 405
Chapter 19 Optimization of Nonviral Gene Therapeutics 423
Chapter 20 Photochemical Internalization: A Technology for Efficient and Site-Specific Gene Delivery 435
Chapter 21 Interactions in Macromolecular Complexes Used as Nonviral Vectors for Gene Delivery 443
PART II Other Therapeutic Strategies
Chapter 22 In Vivo Applications of Morpholino Oligonucleotides 487
Chapter 23 Antisense Oligonucleotide-Based Therapeutics 497
Chapter 24 Development of RNAi Therapeutics 523
Chapter 25 Suicide Gene Therapy 539
Chapter 26 Selectable Markers for Gene Therapy 555
Chapter 27 Embryonic Stem Cells and Their Application in Regenerative Medicine and Tissue Engineering 581
Chapter 28 Polymeric Nano- and Microparticles for the Delivery of Antisense Oligonucleotides and siRNA 599
PART III Gene Expression and Detection
Chapter 29 Deliberate Regulation of Therapeutic Transgenes 619
Chapter 30 Monitoring Gene and Cell Therapies in Living Subjects with Molecular Imaging Technologies 637
Chapter 31 Nonviral Genome Modification Strategies for Gene Therapy: Transposon， Integrase， and Homologous Recombination Systems 677
PART IV Disease Targets and Therapeutic Strategies
Chapter 32 Hematopoietic Progenitor Cells 695
Chapter 33 Gene Therapy for Hematopoietic Disorders 713
Chapter 34 Use of Genetically Modified Stem Cells in Experimental Gene Therapies 731
Chapter 35 Cardiovascular Gene and Cell Therapy 737
Chapter 36 Gene Therapy for Cancer 761
Chapter 37 Molecular Therapy for Type 1 and Type 2 Diabetes 801
Chapter 38 Progress toward Gene Therapy for Cystic Fibrosis 817
Chapter 39 Gene Therapy for Neurological Diseases 833
Chapter 40 Principles of Gene Therapy for Inborn Errors of Metabolism 869
Chapter 41 RNA Interference-Based Gene Therapy Strategies for the Treatment of HIV Infection 881
Chapter 42 Cutaneous Gene Transfer: Cell and Gene Therapy of Skin and Systemic Disorders 889
Chapter 43 Gene Therapy for Childhood Onset Blindness 913
Chapter 44 DNA Vaccines 921
Chapter 45 Immunoisolation for CNS Cell Therapy 949
PART V Clinical Trials and Regulatory Issues
Chapter 46 Cardiovascular Gene Therapy 975
Chapter 47 Gene Therapy for the Treatment of Cancer: From Laboratory to Bedside 1001
Chapter 48 p53 Tumor Suppressor Opens Gateways for Cancer Therapy 1019
Chapter 49 Recombinant Adenoviral-p53 Agent for Treatment of Cancers 1033
Chapter 50 Gene Marking Studies of Hematopoietic Cells 1057
Chapter 51 Regulatory Aspects of Gene Therapy 1071
Index 1087
