Computational protein-protein interactions / edited by Ruth Nussinov, Gideon Schreiber. — Boca Raton, Fla. ; London : CRC Press, c2009. – (58.17421056/C738)

Contents

    Contents
    
    Preface
    Editors
    Contributors
    Chapter 1 Basic Principles of Protein-Protein Interaction 1
    Chapter 2 Low-Resolution Recognition Factors Determine Major Characteristics of the Energy Landscape in Protein-Protein Interaction 21
    Chapter 3 The Molecular Architecture of Protein-Protein Binding Sites 43
    Chapter 4 Mapping Protein Function by Combinatorial Mutagenesis 57
    Chapter 5 The Association of Protein-Protein Complexes 87
    Chapter 6 Computational Simulations of Protein-Protein and Protein-Nucleic Acid Association 109
    Chapter 7 Computational Design of Protein-Protein Interactions 129
    Chapter 8 Protein-Protein Docking 147
    Chapter 9 Prediction of Protein Interaction Sites 167
    Chapter 10 Predicting Molecular Interactions in Structural Proteomics 185
    Chapter 11 Rearrangements and Expansion of the Domain Content in Proteins Frequently Increase the Protein Connectivity in the Protein-Protein Interaction Network 211
    Chapter 12 Intrinsically Disordered Proteins and Their Recognition Functions 223
    Chapter 13 Identification of Druggable Hot Spots on Proteins and in Protein-Protein Interfaces 253
    Chapter 14 Designing Protein-Protein Interaction Inhibitors 281
    Index 305