Application of solution protein chemistry to biotechnology / Roger L. Lundblad. — Boca Raton, Fla. ; London : CRC, c2009. – (58.17421/L962a)

Contents

    Contents
    
    Preface IX
    The Author xi
    Chapter 1 Introduction to the Solution Chemistry of Proteins 1
    Amino Groups 21
    Tyrosine 39
    Cysti ne 62
    Methionine 65
    Tryptophan 68
    Arginine 72
    Histidine 75
    Carboyl Groups 78
    Chemical Cleavage of Peptide Chains 84
    References 87
    Chapter 2 Application of Solution Protein Chemistry to the Study of Biopharmaceutical Conformation 131
    References 143
    Chapter 3 Chemistry of the Attachment of Proteins and Peptides to Solid Surfaces
    DNA and Protein Microarray
    Solid-Phase Matrices (Including Beads) for Attachment of Protein Probes Protein Interaction with Steep100-108 and Titanium109-115
    Chemistry for Attachment of Proteins and Peptides to Solid-Phase Matrices
    References
    Chapter 4 Protein Conjugates 195
    Introduction 195
    Protein Conjugates 198
    Albumin Bioconjugates 204
    Antibody-Protein Conjugates 209
    Direct Labeling of Antibodies with Radioisotopes 213
    Antibody-Drug 213
    Antibody-Radiolabel 217
    Protein-Carbohydrate Conjugates 217
    Polyethylene Glycol 220
    References 230
    Chapter 5 Protein Hydrogels 251
    References 254
    Chapter 6 Adhesives， Glues， and Sealants 281
    Tissue Soldering 283 Proteins as Tissue Solder Material 285
    Fibrin Sealant 289
    Gelatin-Resorcinol-Formaldehyde and Gelatin-Resorcinol-Formaldehyde-Glutaraldehyde 294
    BioGlue 297
    Mussel Adhesive Protein 297
    End Notes 298
    References 299
    Chapter 7 Protein Drug Delivery 327
    References 332
    Chapter 8 Application of Solution Protein Chemistry to Proteomics 339
    References 368
    Chapter 9 Use of Chemical Modification to Produce Biopharmaceutical Products 379
    Chemical Modification of Oligosaccharides/Polysaccharides to Produce Therapeutic Products 380
    Chemical Modification of Nucleic Acids 381
    Chemical Modification and the Manufacture of Therapeutic Proteins 385
    Chemical Glycosylation 385
    Allergoids 389
    Cross-Linkage 391
    Formaldehyde 394
    Active-Site Blocked Enzymes as Competitive Inhibitors 395
    Miscellaneous Chemical Modification of Proteins Having Therapeutic Value 397
    References 399
    Chapter 10 Food and Agricultural Chemistry 411
    References 420
    Index 433