Advances in genetics. v. 64 / edited by Jeffrey C. Hall, Jay C. Dunlap, Theodore Friedmann. — Amsterdam : Elsevier, c2008. – (58.14/A244/v.64)

Contents

    Contents
    
    1 The Inspection Paradox and Whole-Genome Analysis
    I. Inspection Paradox
    II. Homozygosity Mapping
    III. X-Linked Mutations
    IV. Discussion
    References
    2 Gene Expression Studies in Mosquitoes 19
    I. Introduction 20
    II. Study of Gene Expression in Mosquitoes
    III. Concluding Remarks 41
    References 42
    3 Phylogeny of Tec Family Kinases: Identification of a Premetazoan Origin of Btk， Bmx， Itk， Tec， Txk， and the Btk Regulator SH3BP5 51
    I. Tyrosine kinases and the Tec Family 52
    II. Aim of this Review 55
    III. The function of individual domains in TFKs 56
    IV. The ancestry of TFKs 61
    V. SH3BP5—A conserved negative regulator of TFKs 66
    VI. The origin of phosphotyrosine signaling and the role of cytoplasmic tyrosine Kinases 66
    References 68
    4 Therapeutic Approaches to Ion Channel Diseases 81
    I. Introduction 82
    II. Pharmacotherapy of Ion Channelopathies
    III. Molecular Pharmacology of Ion Channels
    IV. Conclusions 132
    References 133