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Molecular biology of the gene / James D. Waston ... [et al]. — 5th ed. — San Francisco : Pearson/Benjamin Cummings ; Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboatory Press, c2004. – (58.1573/W339/5th ed.) |
Contents
Contents
PART 1 CHEMISTRY AND GENETICS 1
1 The Mendelian View of the World 5
2 Nucleic Acids Convey Genetic Information 19
3 The Importance of Weak Chemical Interactions 41
4 The Importance of High-Energy Bonds 55
5 Weak and Strong Bonds Determine Macromolecular Structure 69
PART 2 MAINTENANCE OF THE GENOME 93
6 The Structures of DNA and RNA 97
7 Chromosomes, Chromatin, and the Nucleosome 129
8 The Replication of DNA 181
9 The Mutability and Repair of DNA 235
10 Homologous Recombination at the Molecular Level 259
11 Site-Specific Recombination and Transposition of DNA 293
PART 3 EXPRESSION OF THE GENOME 343
12 Mechanisms of Transcription 347
13 RNA Splicing 379
14 Translation 411
15 The Genetic Code 461
PART 4 REGULATION 479
16 Gene Regulation in Prokaryotes 483
17 Gene Regulation in Eukaryotes 529
18 Gene Regulation during Development 575
19 Comparative Genomics and the Evolution of Diversity 613
PART 5 METHODS 643
20 Techniques of Molecular Biology 647
21 Model Organisms 681
Index 713