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Molecular biology of the gene / James D. Watson ... [et al.]. — 6th ed. — San Francisco : Pearson/Benjamin Cummings ; Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, c2008. – (58.1573/W339/6th ed.) |
Contents
Contents
PART 1 CHEMISTRY AND GENETICS, 1
1 The Mendelian View of the World, 5
2 Nucleic Acids Convey Genetic Information, 19
3 The Importance of Weak Chemical Interactions, 43
4 The Importance of High-Energy Bonds, 57
5 Weak and Strong Bonds Determine Macromolecular Structure, 71
PART 2 MAINTENANCE OF THE GENOME, 95
6 The Structures of DNA and RNA, 101
7 Genome Structure, Chromatin, and the Nucleosome, 135
8 The Replication of DNA, 195
9 The Mutability and Repair of DNA, 257
10 Homologous Recombination at the Molecular Level, 283
11 Site-Specific Recombination and Transposition of DNA, 319
PART 3 EXPRESSION OF THE GENOME, 371
12 Mechanisms of Transcription, 377
13 RNA Splicing, 415
14 Translation, 457
15 The Genetic Code, 521
PART 4 REGULATION, 541
16 Transcriptional Regulation in Prokaryotes, 547
17 Transcriptional Regulation in Eukaryotes, 589
18 Regulatory RNAs, 633
19 Gene Regulation in Development and Evolution, 661
20 Genome Analysis and Systems Biology, 703
PART 5 METHODS, 733
20 Techniques of Molecular Biology, 739
21 Model Organisms, 783
Index, 819