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Eukaryotic transcription factors / by David S. Latchman. — 5th ed. — Amsterdam : Elsevier / Academic Press, c2008. – (58.1483/L351/5th ed.) |
Contents
CONTENTS
List of tables
About the author
Preface
Preface to the fourth edition
Preface to the third edition
Preface to the second edition
Preface to the first edition
Acknowledgements
1. DNA SEQUENCES, TRANSCRIPTION FACTORS AND CHROMATIN STRUCTURE
1.1. The importance of transcription
1.2. Chromatin structure and its remodelling
1.3. DNA sequence elements
1.4. Conclusions
References
2. METHODS FOR STUDYING TRANSCRIPTION FACTORS
2.1. Introduction
2.2. Methods for studying DNA-protein interactions
2.3. Methods for purifying and/or cloning transcription factors
2.4. Use of cloned genes
2.5. Conclusions
References
3. RNA POLYMERASES AND THE BASAL TRANSCRIPTIONAL COMPLEX
3.1. RNA polymerases
3.2. The stable transcriptional complex
3.3. RNA polymerase I
3.4. RNA polymerase III
3.5. RNA polymerase II
3.6. TBP: the universal transcription factor?
3.7. Transcriptional elongation
3.8. Conclusions
References
4. FAMILIES OF DNA BINDING TRANSCRIPTION FACTORS
4.1. Introduction
4.2. The homeodomain
4.3. The two cysteine two histidine Zinc finger
4.4. The multi-cysteine Zinc finger
4.5. The basic DNA binding domain
4.6. Other DNA binding motifs
4.7. Conclusions
References
5 ACTIVATION OF GENE EXPRESSION BY TRANSCRIPTION FACTORS
5.1. Activation domains
5.2. Nature of activation domains
5.3. Interaction of activation domains with the basal transcriptional complex
5.4. Interaction of activation domains with other regulatory proteins
5.5. Effect of transcriptional activators on chromatin structure
5.6. Stimulation of transcriptional elongation
5.7. Conclusions
References
6 REPRESSION OF GENE EXPRESSION BY TRANSCRIPTION FACTORS
6.1. Repression of transcription
6.2. Indirect repression
6.3. Direct repression
6.4. Inhibition by alteration of chromatin structure
6.5. Inhibition of transcriptional elongation
6.6. Conclusions
References
7 REGULATION OF TRANSCRIPTION FACTOR SYNTHESIS
7.1. Transcription factor regulation
7.2. Regulated synthesis of transcription factors
7.3. Mechanisms regulating the synthesis of transcription factors
7.4. Conclusions
References
8 REGULATION OF TRANSCRIPTION FACTOR ACTMTY
8.1. Evidence for the regulated activity of transcription factors
8.2. Regulation by protein-ligand binding
8.3. Regulation by protein-protein interactions
8.4. Regulation by protein modification
8.5. Regulation by protein degradation and processing
8.6. Role of regulated activity
8.7. Conclusions
References
9. TRANSCRIPTION FACTORS AND HUMAN DISEASE
9.1. Diseases caused by transcription factor mutations
9.2. Cancer
9.3. Cellular oncogenes and cancer
9.4. Anti-oncogenes and cancer
9.5. Transcription factors and treatment of human disease
9.6. Conclusions
References
10. CONCLUSIONS AND FUTURE PROSPECTS