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Gene function analysis / edited by Michael F. Ochs. — Totowa, N.J. : Humana, c2007. – (58.17/M592/v.408) |
Contents
Contents
Preface vii
Contributors xiii
PART I COMPUTATIONAL METHODS I
1 Gene Function Inference From Gene Expression of Deletion Mutants
2 Association Analysis for Large-Scale Gene Set Data
3 Estimating Gene Function With Least Squares Nonnegative Matrix Factorization
4 From Promoter Analysis to Transcriptional Regulatory Network Prediction Using PAINT
5 Prediction of Intrinsic Disorder and Its Use in Functional Proteomics
PART II COMPUTATIONAL METHODS II
6 Sybil: Methods and Software for Multiple Genome Comparison and Visualization
7 Estimating Protein Function Using Protein-Protein Relationships
8 Bioinformatics Tools for Modeling Transcription Factor Target Genes and Epigenetic Changes
9 Mining Biomedical Data Using MetaMap Transfer (MMTx) and the Unified Medical Language System (UMLS)
10 Statistical Methods for Identifying Differentially Expressed Gene Combinations
PART III EXPERIMENTAL METHODS
11 Gene Function Analysis Using the Chicken B-Cell Line DT40
12 Design and Application of a shRNA-Based Gene Replacement Retrovirus
13 Construction of Simple and Efficient DNA Vector-Based Short Hairpin RNA Expression Systems for Specific Gene Silencing in Mammalian Cells
14 Selection of Recombinant Antibodies From Antibody Gene Libraries
15 A Bacterial/Yeast Merged Two-Hybrid System: Protocol for Yeast Screening With Single or Parallel Baits
16 A Bacterial/Yeast Merged Two-Hybrid System: Protocol for Bacterial Screening
17 Engineering Cys2His2 Zinc Finger Domains Using a Bacterial Cell-Based Two-Hybrid Selection System