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Mechanisms in transcriptional regulation / Albert J. Courey. — Malden, MA : Blackwell Publishing, c2008. – (58.1482/C859) |
Contents
Contents
List of boxes
Preface
Acknowledgments
1 The vocabulary of transcription
1.1 Introduction
1.2 The vocabulary of transcription
1.3 Evolutionarily conserved mechanisms of transcription
1.4 What's coming up
Problems
Further reading
2 RNA polymerases and the transcription cycle
2.1 Introduction
2.2 Core RNA polymerases
2.3 Transcriptional elongation
2.4 Transcriptional initiation
2.5 Transcriptional termination
2.6 Summary
Problems
Further reading
3 The eukaryotic basal machinery
3.1 Introduction
3.2 The class II core promoter
3.3 The catalog of factors
3.4 Pathway to the preinitiation complex
3.5 Promoter recognition and nucleation of the PIC by TFIID
3.6 TFIIB: a functional analog of bacterial c~ factors
3.7 TFIIH in promoter opening and promoter clearance
3.8 Summary
Problems
Further reading
4 Mechanisms of transcriptional activation
4.1 Introduction
4.2 Paradigms from E. coli
4.3 Eukaryotic activators and their targets
4.4 Summary
Problems
Further reading
5 Transcriptional control through the modification of chromatin structure
5.1 Introduction
5.2 Chromatin structure
5.3 Histone modification
5.4 ATP-dependent chromatin remodeling enzymes
5.5 Protein motifs that recognize modified histones
5.6 Coordination of activator-coactivator interactions
5.7 Summary
Problems
Further reading
6 Epigenetic control of transcription
6.1 Introduction
6.2 Heterochromatic silencing
6.3 Epigenetic control by Polycomb and Trithorax group proteins
6.4 X chromosome inactivation: parallels to heterochromatic and Polycomb group silencing
6.5 Summary
Problems
Further reading
7 Combinatorial control in development and signal transduction
7.1 Introduction
7.2 Synergy and antagonism
7.3 Synergy and the enhanceosome
7.4 Antagonism and stripe formation
7.5 Antagonism and the signal-mediated switch
7.6 Summary
Problems
Further reading
Answers to problems
Glossary
Index
