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Drosophila : a toolbox for the study of neurodegenerative disease / edited by Amritpal Mudher, Tracey Newman. — New York : Taylor & Francis Group, 2008. – (59.18576/D787t) |
Contents
Contents
Contributors
Preface
1. Modelling neurodegenerative diseases in Drosophila
1 Background
2 Modelling neurodegenerative diseases in Drosophila
3 How has Drosophila been used to study human diseases?
2. Drosophila genetics for the analysis of neurobiological disease
1 Introduction
2 The life cycle of Drosophila melanogaster
3 The nervous system at key developmental stages
4 Genetic techniques
5 The P-element as a vector
6 Advanced genetic techniques
7 Conclusions References
3. Using Drosophila models to unravel pathogenic mechanisms that underlie neurodegeneration in tauopathies 25
1 Introduction
2 Does tau play a role in neurodegeneration? Lessons from tauopathies
3 How is tau abnormal in tauopathies?
4 Drosophila models of tauopathies
5 Overexpression of tau is toxic
6 Overexpression of tau disrupts neuronal function
7 Phosphorylation state of tau underlies the tau phenotypes
8 Clearance of tau alleviates its toxicity
9 Conclusions
4. Modelling cell and isoform type specificity of tauopathies in Drosophila
1 Introduction
2 Modelling tauopathies
3 Cell type-specific processing of human tau proteins in Drosophila
4 Modelling tau-dependent learning and memory deficits
5 Conclusions
5. Using a Drosophila model of Alzheimer's disease
1 Introduction
2 Making a model of Alzheimer's disease
3 Generation， optimisation and quantitation of phenotypes
4 Genetic screens in a Drosophila model of Alzheimer's disease yield pathogenic pathways
5 Identification of candidate genes
6 Clinical relevance
7 Conclusion
6. Amyloid peptides and ion channel function in Drosophila models of Alzheimer's disease
1 Introduction
2 Vertebrate models of Alzheimer's disease
3 Caenorhabditis elegans models of Alzheimer's disease
4 Drosophila rnelanogaster models of Alzheimer's disease
5 Studies on the Drosophila larval nervous system
6 Conclusions
7. Genetic models of Parkinson's disease: mechanisms and therapies
1 Introduction
2 The ct-synuclein transgenic Drosophila model of Parkinson's disease
3 Loss-of-function models of Parkinson's disease
4 Conclusions
8. Modelling lysosomal storage disease in Drosophila
1 Introduction
2 Classifying the LSD based on stored material and genetic deficits
3 The neuronal phenotype of lysosomal storage
4 Functional consequences of lysosomal storage
5 Current Drosophila models of known LSDs
6 Generating novel Drosophila models of LSDs
7 Possible Drosophila models of LSDs
8 Conclusions and outlook
9. Drosophila melanogaster in the study of epilepsy
1 Introduction
2 Epilepsy models
3 Seizure phenotypes in Drosophila
4 Neuronal homeostasis and contribution to seizure
5 Concluding remarks
10. Hereditary spastic paraplegia genes in Drosophila: dissecting their roles in axonal degeneration and intracellular traffic
1 Introduction
2 Pathogenesis and gene roles
3 Conclusion
11. Triplet repeat diseases: the role of fly models in understanding disease mechanisms and designing possible therapies
1 Triplet repeat disorders
2 Diseases caused by expansions of glutamine repeats
3 Diseases caused by expansions/duplications of alanine repeats
4 Lessons from Drosophila models of triplet repeat diseases
5 Conclusion
Index
